Without an appendix, you are less likely to have Parkinson's disease



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More and more research indicates the role of the intestines and the immune system in the development of brain disorders such as Parkinson's disease. It now emerges from research by the Van Andel Research Institute that the removal of the appendix, the worm-shaped appendix of the appendix, reduces the risk of developing the Parkinson disease.

For the study, scientists studied an important set of medical data gathering between 1964 and 2016 a group of 1.6 million inhabitants in Sweden. Among the participants whose appendix was removed, Parkinson's disease occurred at 1.6 out of 100,000. Among the volunteers who still had an appendix, there were more with Parkinson's disease. 1.98 per 100,000 participants were suffering from a brain disorder.

Although there is no real test for Parkinson's disease, withdrawal from the appendix seems to delay diagnosis for more than 3.5 years, scientists write.

In the appendix, much of the protein contains alpha-synuclein (aS). When the protein accumulates in the brain, moist bodies develop, characteristic of Parkinson's disease. The researchers therefore also examined the presence of protein in the appendix of people with and without Parkinson's disease. Remarkably, αS was also included in the schedule of healthy participants. Until now, it was thought that this was the case only in people with Parkinson's disease.

Scientists conclude that the appendix and αS proteins play a role in the development of Parkinson's disease, but they think that more is needed. They will now study what.

The removal of the appendix in patients with Parkinson's disease had no other effect on the course of the disease. Scientists will now study which treatments are effective.

The results are published in the journal Science Translational Medicine

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