New research shakes family tree of laziness



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<div data-thumb = "https://3c1703fe8d.site.internapcdn.net/newman/csz/news/tmb/2019/shakingupthe.jpg" data-src = "https://3c1703fe8d.site.internapcdn.net/ newman / gfx / news / hires / 2019 / shakingupthe.jpg "data-sub-html =" In the tree, clockwise from the left: extinct laziness of the West Indies (acratocnus), lazy or three-fingered paralysis ((Bradypus) and two-fingered sloth or an existing one (Choloepus). From left to right on the floor, some typical giant floor sloths: Mylodon (South America), Megalonyx (North America), and Megatherium (South America). According to new molecular studies, Bradypus is most closely related to a group that includes Megalonyx and Megatherium. Choloepus is linked to Mylodonbut acratocnus and his West Indian parents are a separate branch from that of all other lazy people. Human to scale: 1.8.5 m (6 ft 1 in). Credit: Jorge Blanco ">

<img src = "https://3c1703fe8d.site.internapcdn.net/newman/csz/news/800/2019/shakingupthe.jpg" alt = "Shake the family tree from laziness" title = "In the Tree, go clockwise from left to right: Antillean laziness extinguished (acratocnus), lazy or three-fingered paralysis ((Bradypus) and two-fingered sloth or an existing one (Choloepus). From left to right on the floor, some typical giant floor sloths: Mylodon (South America), Megalonyx (North America), and Megatherium (South America). According to new molecular studies, Bradypus is most closely related to a group that includes Megalonyx and Megatherium. Choloepus is linked to Mylodonbut acratocnus and his West Indian parents are a separate branch from that of all other lazy people. Human to scale: 1.8.5 m (6 ft 1 in). Credit: Jorge Blanco "/>
In the tree, in a clockwise direction from the left: lazy West Indiesacratocnus), lazy or three-fingered paralysis ((Bradypus) and two-fingered sloth or an existing one (Choloepus). From left to right on the floor, some typical giant floor sloths: Mylodon (South America), Megalonyx (North America), and Megatherium (South America). According to new molecular studies, Bradypus is most closely related to a group that includes Megalonyx and Megatherium. Choloepus is linked to Mylodonbut acratocnus and his West Indian parents are a separate branch from that of all other lazy people. Human to scale: 1.8.5 m (6 ft 1 in). Credit: Jorge Blanco

New studies of two research teams published today in journals Nature Ecology and Evolution and Current biology challenge decades of accepted scientific advice regarding the evolutionary relationships of lazy trees and their missing relatives. The research teams used different molecular tools (collagen protein in one case and the mitochondrial genome in the other), but they almost achieved the same results. Simultaneous results are important because they provide molecular evidence that seems to overturn a long-standing consensus, based on the study of anatomical features, on the relationship between major lazy groups.

Corresponding authors Ross D. E. MacPhee of the American Museum of Natural History and Frédéric Delsuc of the CNRS of the University of Montpellier indicated that, although their research groups work separately, they were in communication.

"Each of us was initially surprised by our results as they totally contradicted what appeared to be the accepted vision based on anatomy," said Delsuc.

"Exceptional results require exceptional verification," said MacPhee, a curator at the Museum's mammal department. "That is why we agreed with the journals to simultaneously publish our articles, to emphasize that corroboration is a crucial element of good science."

To begin their work, the teams had to collect molecular information not only from the two types of lazy living trees, the unau, the genus Choloepus (also known as the two-fingered sloth) and the ma, of the genus Bradypus (lazy), but also a wide range of extinct forms, including the big lazy ground, that we can see in many natural history museums. The Delsuc team has targeted the DNA content in the mitochondria, the cellular "energetic motors" that exist in large numbers in body tissues and can be recovered using old methods. DNA capture from well preserved fossil materials. However, compared to the nuclear genome, the information contained in the mitochondrial genome is limited and can sometimes be incompatible with the evolution of evolution.

<div data-thumb = "https://3c1703fe8d.site.internapcdn.net/newman/csz/news/tmb/2019/1-shakingupthe.jpg" data-src = "https: //3c1703fe8d.site.internapcdn. net / newman / gfx / news / hires / 2019/1-shakingupthe.jpg "data-sub-html =" A photo of a fossil of lestodon, a lazy mylodontoid soil from South America, exhibited at the American Museum of Natural History. Credit: AMNH / D. Finnin ">

<img src = "https://3c1703fe8d.site.internapcdn.net/newman/csz/news/800/2019/1-shakingupthe.jpg" alt = "Shaking the Family Tree of Laziness" title = " A photo of a fossil of lestodon, a lazy mylodontoid soil from South America, exhibited at the American Museum of Natural History. Credit: AMNH / D. Finnin "/>
A photo of a fossil of lestodon, a lazy mylodontoid soil from South America, exhibited at the American Museum of Natural History. Credit: AMNH / D. Finnin

Importantly, the results of the other team's study, which analyzed collagen protein, were consistent with the mitochondrial study. Paleoproteomics, or the use of protein evidence for taxonomic purposes, is a relatively new area, but collagen type 1 ("bone") has become an increasingly important source of information in mammalian paleontology, for two years. reasons: it degrades more slowly than DNA, and it can be found in large quantities in well-preserved fossils because it accounts for 80 to 90% of the organic fraction of the bone. The genes providing the instructions for the synthesis of bone collagen reside in the nucleus and, because of the precise relationship between the constituent elements of a given gene and the protein for which it encodes, the amino acids of the protein reflect the present information. in the gene at the level of the protein. Level of DNA. Thus, between them, the two studies sampled both parts of the genome, both nuclear and mitochondrial.

"Structural proteins such as collagen potentially last much longer after death than the relatively fragile DNA molecule," said Samantha Presslee, lead author of the publication. Nature Ecology and Evolution paper and doctoral student at York University. "This means that scientists can extract and interpret protein evidence from a wide range of extinct species far beyond the current scope of ancient DNA."

Other proteomic studies have revealed the presence of high quality collagen from specimens aged 3.8 million years old, originating from an island in the Canadian Arctic. In the case of the laziness study, the earliest recovery was obtained with a fossil aged 120,000 to 400,000 years; older specimens were tested but did not provide any useful information.

"Having before us the results of the two sources of molecular information, we knew that we were staying on solid ground and that it was time to review the evolution and classification of laziness," he said. Hendrik Poinar of the Ancient DNA Center at McMaster University. who was also a corresponding author on the mitogenomic paper.

With their long arms, crocheted claws and backward locomotion, the six living lazy species seem remarkably similar, but research has shown that they have acquired their adaptation to life in trees independently. thanks to a phenomenon called evolutionary convergence. Molecular studies also confirmed the converging origins, but most other inferences about the evolutionary relationships of laziness were unfounded. For example, the three-toed sloths have long been considered as different from the other anatomically lazy ones, so that they have been classified into a completely distinct evolutionary branch. The evidence for mitochondrial and protein proteins indicates that this view is false: Bradypus bends well in Megatherioidea, a group that also included the largest of all lazy, Megatherium, a giant elephant-sized floor. Similarly, the unaus (two-fingered lazy) belonged to another major group called the mylodontoids, although they had already been placed in Megalonychidae, a family originally defined to include the lazy North soil. American extinct Megalonyx and several islands species that lived in the West Indies until a few thousand years ago.

<div data-thumb = "https://3c1703fe8d.site.internapcdn.net/newman/csz/news/tmb/2019/2-shakingupthe.jpg" data-src = "https: //3c1703fe8d.site.internapcdn. net / newman / gfx / news / hires / 2019/2-shakingupthe.jpg "data-sub-html =" A photo of a fossil of Megalonyx, a lazy megatherioid soil from North America, exhibited at the American Museum of Natural History. Credit: AMNH / D. Finnin ">

<img src = "https://3c1703fe8d.site.internapcdn.net/newman/csz/news/800/2019/2-shakingupthe.jpg" alt = "Shaking the Family Tree of Laziness" title = " A photo of a fossil of Megalonyx, a lazy megatherioid soil from North America, exhibited at the American Museum of Natural History. Credit: AMNH / D. Finnin "/>
A photo of a fossil of Megalonyx, a lazy megatherioid soil from North America, exhibited at the American Museum of Natural History. Credit: AMNH / D. Finnin

Each team also attempted a molecular dating to interpret its evidence in the context of the fossil record of laziness in order to predict the timing of the separation of the different main groups. This led to another major surprise: the combined molecular evidence suggests that West Indian sloths, known as megalocnids, have diverged from the ancestors of megatherioids and mylodontoids over 30 million years ago. years. The first lazy ones who reached the Greater Antilles may have entered through a temporary land connection between these islands and South America. In taxonomic terms, this makes them the closest relatives or the sister group of all the other lazy ones, whereas they were previously considered to be a minor group evolving late in megatherioid radiation. Another finding in contradiction with traditional taxonomy is that Megalonyx, previously thought to be a close relative of the unau (two fingered sloth), seems to be more closely related to ia (three fingered sloth).

"The combined molecular results are surprising at many levels," said Graham Slater, an assistant professor of geophysical science at the University of Chicago, involved in protein paper. "Not only do they rewrite the lazy classification, but they largely suggest what we knew how lazy people have evolved in. We usually think that lazy people today have evolved independently for living in trees from an ancestor living on the land, but our findings suggest that basal, or ancestral laziness, may have been at home at one time. "

One of the reasons for this reflection is that most lazy West Indians seem to be very arboreal, with adaptations showing adaptations quite similar to those of the lazy living.

"Although molecular results are at odds with current paleontological conceptions based on anatomical features, there can only be one life story," MacPhee said. "The job now is to reconcile these different methods of inference, which means a lot more work on everyone's part.We will learn a lot, and it's exciting."

"Until recently, extinct organisms could only be included in genealogical analyzes of living organisms using data based on their morphology or appearance," said Simon Malcomber, director of the program. at the National Science Foundation, which funded paleoproteomic research. "This research shows how the combined molecular analyzes of missing and living parents can provide startling new – and exciting – information about the evolution of life on Earth.These new methods of extraction open the door to new examining the relationships between living and extinct organisms, and how the diversity of life has changed over time ".


Researchers discover genomic information linking extinct giant terrestrial sloth to modern species


More information:
Samantha Presslee et al, Palaeoproteomics solves the relations of laziness, Nature Ecology & Evolution (2019). dx.doi.org/10.1038/s41559-019-0909-z

Provided by
American Museum of Natural History


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New research revolutionises family tree of laziness (June 6, 2019)
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