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Media advisory
Monday July 19, 2021
The presence of certain features on CT scans may guide follow-up treatment.
What
A new study published in JAMA Neurology suggests that certain features that appear on CT scans help predict outcomes after mild traumatic brain injury (TBI). The patterns detected on the scans can help guide follow-up treatment as well as improve the recruitment and design of research studies for head injury clinical trials.
Researchers led by Geoffrey Manley, MD, Ph.D., professor of neurological surgery at the University of California, San Francisco, performed CT scans in 1,935 subjects with mild TBI and followed their results up to 12 months after the injury.
This research was part of the Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) study, a large research effort funded by the National Institutes of Health to improve understanding of the short- and long-term effects of head injuries. and to identify potential treatments.
Researchers identified three distinct sets of patterns on CT scans, indicating different types of damage after head trauma that were associated with varying outcomes. The results suggest that contusion (bleeding into brain tissue), subarachnoid hemorrhage (bleeding into the cerebrospinal fluid above the brain), subdural hematoma (bleeding between the brain and the thick layer covering the brain) and intraventricular hemorrhage (bleeding into fluid-filled spaces in the center of the brain) were associated with poorer outcomes 12 months after injury. Epidural hematoma, which describes hemorrhage between the skull and the outer brain envelope known as the dura mater, was associated with incomplete recovery at two weeks and three months, but was not linked to negative results longer term.
The TRACK-TBI study was designed and performed in collaboration with the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study involving 2594 TBI subjects. Both sets of results showed similar trends on CT scans and similar associations between CT abnormalities and clinical outcomes.
More research is needed to understand the effects of head trauma on brain structure and function, and how different types of injuries can lead to varying short- and long-term outcomes.
who
Nsini Umoh, Ph.D., Program Director, National Institute of Neurological Disorders and Stroke (NINDS), NIH. To arrange an interview, please contact [email protected]
Item
Yuh EL et al., Pathologic CT Features Associated with Adverse Findings After Mild Traumatic Brain Injury, JAMA Neurology, July 19, 2021. DOI: 10.1001 / jamaneurol.2021.2120
This study was supported by NINDS (NS1365885).
NINDS is the largest national funder of brain and nervous system research. The mission of NINDS is to research fundamental knowledge about the brain and nervous system and to use this knowledge to reduce the burden of neurological disease.
About the National Institutes of Health (NIH):The NIH, the national agency for medical research, comprises 27 institutes and centers and is part of the US Department of Health and Human Services. The NIH is the principal federal agency that conducts and supports basic, clinical, and translational medical research, and studies the causes, treatments, and cures for common and rare diseases. For more information about the NIH and its programs, visit www.nih.gov.
NIH… Transforming Discovery into Health®
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