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Patients whose appendix has been removed are three times more likely to develop Parkinson's disease than those who do not, according to a new study.
After analyzing more than 62 million patient records, in the largest observational study of Parkinson's disease and its appendicectomies, a team of gastroenterologists from Cleveland University Hospital discovered what many other health had not yet.
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"Recent research into the cause of Parkinson's disease has focused on alpha-synuclein, a protein found in the early digestive tract of Parkinson's disease," said Dr. Mohammed Sheriff, lead author of the project. in a press release. "That's why scientists around the world have been looking at the gastrointestinal tract, including the appendix, for evidence on the development of Parkinson's disease."
The team of doctors found that, according to a national database of more than 62 million people out of 488,190 patients who had an appendectomy, more than 9% had developed Parkinson's disease. A significant difference between 0.29% of developing patients with Parkinson's who have never had their appendix removed.
"In the United States, it is the largest study to date. So we wanted to know what would be the association between this database and whether the differences were consistent from one subgroup to another, "said Dr. Gregory Cooper, Research Advisor at UHCMC at Fox News. .
It was not the first time a team had tried to discover an association between surgery and disease. Previous research was inconsistent and resulted in conflicting conclusions from their peers. For example, in Europe, a study found that people whose appendix had been removed earlier were less likely to develop the disease.
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It was the many inconsistent results of other researchers that pushed Cooper to lead the team of physicians toward more robust results.
"Sometimes, when a study is done in a single hospital, there may be a selection bias as to who enters or does not study," Cooper said. "We think our results are potentially more generalizable to the general population."
Cooper acknowledged the limitations of his investigation, saying they had limited access to patients' medical records and could not consider variables such as family history and prescriptions.
"This research shows a clear relationship between the appendix, or the elimination of the appendix, and Parkinson's disease, but it is only an association," Sheriff said in a press release.
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The Sheriff will present this study at the Digestive Diseases Digest Week Conference, May 18-21. Cooper hopes that their medical investigations will open the door to more research on the association between the two conditions.
"We make these observations but we can not really identify the mechanism, which would give impetus to [other doctors] do something in the lab, "Cooper said.
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