Drug resistance: the next target for cancer treatment



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Can a new research institute usher in a new era of cancer management? Nigel Hawkes investigation

Cancer will be defeated only by its ability to evolve faster than the drugs that treat it, decided the Institute of Cancer Research.

He launched a new program to tackle what his general manager, Paul Workman, calls "the biggest challenge in cancer biology": controlling the resistance to chemotherapy induced by Darwinian selection.

"Many patients respond well to drugs, but months or years later, tumors start to grow again," he said at a briefing at the Science Media Center in London on May 15. "Most cancer cells may be sensitive to the drug, but a small number of them are resistant. The vast majority of cancer deaths result from the formation of new drug-resistant cells. "

The perception is not new, he conceded, but it was fully taken into account with the development of new techniques …

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