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A man felt drunk even though he did not drink alcohol.
The 47-year-old suffered from intestinal fermentation syndrome, also known as auto-brewing syndrome (ABS). This rare disease involves excessive fungal growth in the intestine which feeds on carbohydrates and then fuels the production of ethanol. Often times, ABS is linked to an excessive amount of yeast in the gut.
According to a case study published this month in the Annals of Internal Medicine, clinicians tried putting the patient on a low-carbohydrate diet and antifungal therapy, but signs of poisoning persisted.
Auto-brewing syndrome is a rare condition involving excessive fungal growth in the gut and the production of ethanol, leaving the person intoxicated.
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The poisoning was so chronic that the man even “lost his driver’s license after a random police check,” according to an Insider report.
Clinicians then turned to fecal microbiota transplantation, or in other words, a poo transplant. Bacteria present in the faeces were transferred to the patient’s small intestine. The transplant came from the 22-year-old man’s daughter and her symptoms were gone, at least until her last follow-up at 34 months, according to the outlet.
The authors of the report said the case would be the “first successful treatment of a patient with chronic intestinal fermentation syndrome using fecal microbiota transplantation.”
Fecal transplants should be considered in similar cases, the researchers said, per Insider.
People with diabetes, cirrhosis, or people who have had digestive tract surgery are at a higher risk of auto-brewing syndrome because the fungus feeds on high blood sugar, the outlet reported.
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In recent years, there have been other reports of the auto-brewery syndrome, sometimes also referred to as “drunkenness disease”. In October, for example, a case study published in BMJ Open Gastroenterology detailed a man’s experience with the syndrome he said developed after completing a series of antibiotics.
In another case, doctors detailed the ABS case of a Chinese. The amount of alcohol-producing bacteria in his gut potentially led him to develop non-alcoholic fatty liver disease which had “severely” damaged his liver, according to a report at the time.
Madeline Farber of Fox News contributed to this report.
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