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It is estimated that prostate cancer affects one in nine men in their lifetime and that prostate cancer kills more people than breast cancer. With these disturbing statistics, many are wondering why the disease is on the rise and what could be the cause. According to research, men who need fertility treatment run a greater risk of developing the disease. Research has suggested that men who need fertility treatment to help them have children have an increased risk of prostate cancer.
Experts believe that biological problems associated with infertility increase the chances of developing the disease and lead to prostate cancer earlier in life.
The new study compared the risk and severity of prostate cancer between men needing fertility treatment and men who conceived naturally.
Data from 1,181,490 children born alive in Sweden between 1994 and 2014 and on the same number of fathers were analyzed for the study.
In the group, 20,618 men gave birth to a child by IVF (1.7%), 14,882 by intracytoplasmic injection of sperm (ICSI, where the sperm is injected directly into the egg, 1,3 %) and 1,145,990 by natural design (97%). hundred).
Overall, after taking into account prostate cancer, it was 0.37% in the IVF group, 0.36% in the ICSI group and 0.28% in the natural conception group that developed cancer of the prostate group. prostate.
The results showed that the risk of prostate cancer was 64% higher among men needing ICSI, while the risk of prostate cancer was 33% among those who needed IVF.
Men needing fertility treatment have also developed cancer earlier.
They were 86% more likely to develop prostate cancer by the age of 55 if they had undergone an ICSI and 51% were more likely to have needed IVF. .
In the British Medical Journal (BMJ), the team led by experts from Lund University, Sweden, said: "The main finding of this study, which includes virtually all men who fathered a child in Sweden during two decades, is that thanks to assisted procreation had a remarkably high risk of prostate cancer ".
Researchers have suggested that men needing fertility treatment are screened earlier for the disease.
And they said that abnormalities on the Y chromosome related to both infertility and prostate cancer could offer a possible biological explanation to the results.
Allan Pacey, Professor of Andrology at the University of Sheffield, said: "A number of studies have suggested in recent years that a diagnosis of male infertility, due to low sperm count or low motility of spermatozoa, could be a marker for future health conditions in men.
"As such, it has been proposed that male infertility can serve as" canary in the coal mine "for men's health, to which men and doctors should be better informed.
"This study is excellent and adds new evidence to the theory of" canary in the coal mine "by showing that Swedish men who became fathers using assisted procreation techniques (such as ICSI) are at increased risk of prostate cancer later in life.
"It's important to point out that it's not because assisted reproduction techniques continue to cause prostate cancer, but probably because both have a common cause in some way.
"Maybe all men diagnosed with a fertility problem in their twenties or thirties should receive a leaflet explaining what it might mean for them in their fifties and sixties so that they can be aware of future problems and be encouraged to consult their general practitioner a little faster than often. "
Simon Grieveson of Prostate Cancer UK said: "It is extremely important to continue research to understand who is at greatest risk for prostate cancer, however, we should not draw conclusions about the impact of fertility treatment. only on the basis of this study. "
"We think it is important for all men to be aware of the risks of prostate cancer and men concerned about the disease to talk to their GP, but the results for couples considering fertility treatment should not be put off. " Researchers suggested men who need fertility treatment should be screened for the disease sooner than at the present time.
And they said that abnormalities on the Y chromosome related to both infertility and prostate cancer could offer a possible biological explanation to the results.
Allan Pacey, Professor of Andrology at the University of Sheffield, said: "A number of studies have suggested in recent years that a diagnosis of male infertility, due to low sperm count or low motility of spermatozoa, could be a marker for future health conditions in men.
"As such, it has been proposed that male infertility can serve as" canary in the coal mine "for men's health, to which men and doctors should be better informed.
"This study is excellent and adds new evidence to the theory of" canary in the coal mine "by showing that Swedish men who became fathers using assisted procreation techniques (such as ICSI) are at increased risk of prostate cancer later in life.
"It's important to point out that it's not because assisted reproduction techniques continue to cause prostate cancer, but probably because both have a common cause in some way.
"Maybe all men diagnosed with a fertility problem in their twenties or thirties should receive a leaflet explaining what it might mean for them in their fifties and sixties so that they can be aware of future problems and be encouraged to consult their general practitioner a little faster than often. "
Simon Grieveson of Prostate Cancer UK said: "It is extremely important to continue research to understand who is at greatest risk for prostate cancer, but we should not draw conclusions about the impact of fertility treatment. only on the basis of this study. "
"We think it's important for all men to be aware of the risks of prostate cancer, and men concerned about the disease should talk to their doctor.
"However, these results should not put off couples who are considering fertility treatment." Symptoms of prostate cancer include frequent urination, low or interrupted urinary flow, urge to urinate at night, blood in the urine, and erectile dysfunction.
If you think that you or one of your acquaintances are showing signs of prostate cancer, it is essential to talk to your doctor about the possible cause.
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