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Scientists could perhaps reverse the aging process, might suggest a new study.
According to the new study, volunteers who received a cocktail of drugs for a year lose on average 2.5 years of their biological age. Research has shown that the marks on their genomes that represent their "epigenetic clock" as well as their immune system have improved despite the passage of time.
The scientists involved in the study were shocked by the results.
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"I was expecting a slowing down of the clock, but not a reversal," said researcher Steve Horvath of the University of California Los Angeles. Naturewho first reported the results. "It was a bit futuristic."
The scientists point out that the study was conducted with a very limited number of participants: only nine people took the cocktail of drugs and there was no control group. But if this is confirmed by other research, it could have huge impacts on health care, the treatment of diseases and the way people think about aging, they said.
1/9 Structures of soap bubbles with colors and patterns of light interference
The bubbles want to optimize space and minimize their area for a given volume of air. This unique phenomenon makes it a reliable and useful tool in many areas of research. In particular, the science of materials and "packaging" – how things complement each other. The walls of bubbles drain under the effect of gravity, thin at the top and thick at the bottom and hinder the moving light waves to create bands of colors. Black dots indicate that the wall is too thin for interference colors, indicating that the bubble is about to burst! – Kym Cox
Kym Cox / RPS
2/9 Jellyfish in reverse, Cassiopea xamachana
Instead of swimming, this species spends its time throbbing in the water. Their diet is the marine plankton and their coloring comes from the absorption of algae in the water. Some species of jellyfish have been documented eating plastic in the ocean. One theory suggests that algae grow on plastic. By breaking down, algae create a dimethyl sulphide smell that attracts hungry animals. – Mary Anne Chilton
Mary Anne Chilton / RPS
3/9 Tribolium confusum. Beetle of confused flour.
This small beetle is a pest in stored grain and flour products. Scanning electron micrograph in Photoshop. – David Spears
David Spears / RPS
4/9 NGC7000 North American Nebula
The North American Nebula, NGC7000, is an emission nebula located in the constellation Cygnus, near Deneb. The remarkable shape of the nebula resembles that of the North American continent, completed by the Gulf of Mexico. The Cygnus Wall, term for the "part of Mexico and Central America" of the North American Nebula, presents the most concentrated star formations of the nebula. – Dave Watson
Dave Watson / RPS
5/9 Security Corona
A safety pin is connected to a high voltage AC generator. The pin ionizes the air that surrounds it. When the electrons fall back on an atom, the excess energy is emitted as a photon, which generates the corona glow around the pin. The fuzziness of the pin comes from the fact that the camera did not capture the reflected light on the pin, but rather the light emitted by the ionized light that surrounds it. – Richard Germain
Richard Germain / RPS
6/9 Calm of eternity
Mountains of the Himalayas, Nepal. High mountain lake of Gosaikunda. Point of fire – 4400m. The Milky Way is the galaxy that contains the solar system, with the name describing the appearance of the galaxy from the Earth: a band of blurred light seen in the night sky formed of stars that can not be individually distinguished at the naked eye. The Milky Way is a barred spiral galaxy whose diameter varies between 150,000 and 200,000 light-years. It is estimated that it contains 100, 400 billion stars
Yevhen Samuchenko
Yevhen Samuchenko / RPS
7/9 Beetle
Beetle. Optical microscopy 5x magnification. – Viktor Sykora
Viktor Sykora / RPS
8/9 Mapping1_OxygenIb_PEM
Final major project for a Master's degree in photography at Falmouth University. Project: Mapping 1, Post-exercise Malaise. Cartography 1, focuses on the discovery of research underlying myalgic encephalomyelitis. By exploring the perspective, complexities and multidisciplinary scientific collaborations, I create images that explain, reveal and connect us consciously with the ambiguous and the unknown. – Yasmin Crawford
Yasmin Crawford / RPS
9/9 Lovell Telescope Series 1c
The Lovell telescope from the Jodrell Bank has always fascinated me since I went on a school trip. Here, I wanted to take a series of snapshots closer, more detailed and more honest than we often see. By exploring the multitude of shapes and exposing the wear of the telescope, each photo in the series is isolated or can be viewed collectively. They present in any case a powerful representation of the machine that helps humanity to understand the space and the time. – Marge Bradshaw
Marge Bradshaw / RPS
1/9 Structures of soap bubbles with colors and patterns of light interference
The bubbles want to optimize space and minimize their area for a given volume of air. This unique phenomenon makes it a reliable and useful tool in many areas of research. In particular, the science of materials and "packaging" – how things complement each other. The walls of bubbles drain under the effect of gravity, thin at the top and thick at the bottom and hinder the moving light waves to create bands of colors. Black dots indicate that the wall is too thin for interference colors, indicating that the bubble is about to burst! – Kym Cox
Kym Cox / RPS
2/9 Jellyfish in reverse, Cassiopea xamachana
Instead of swimming, this species spends its time throbbing in the water. Their diet is the marine plankton and their coloring comes from the absorption of algae in the water. Some species of jellyfish have been documented eating plastic in the ocean. One theory suggests that algae grow on plastic. By breaking down, algae create a dimethyl sulphide smell that attracts hungry animals. – Mary Anne Chilton
Mary Anne Chilton / RPS
3/9 Tribolium confusum. Beetle of confused flour.
This small beetle is a pest in stored grain and flour products. Scanning electron micrograph in Photoshop. – David Spears
David Spears / RPS
4/9 NGC7000 North American Nebula
The North American Nebula, NGC7000, is an emission nebula located in the constellation Cygnus, near Deneb. The remarkable shape of the nebula resembles that of the North American continent, completed by the Gulf of Mexico. The Cygnus Wall, term for the "part of Mexico and Central America" of the North American Nebula, presents the most concentrated star formations of the nebula. – Dave Watson
Dave Watson / RPS
5/9 Security Corona
A safety pin is connected to a high voltage AC generator. The pin ionizes the air that surrounds it. When the electrons fall back on an atom, the excess energy is emitted as a photon, which generates the corona glow around the pin. The fuzziness of the pin comes from the fact that the camera did not capture the reflected light on the pin, but rather the light emitted by the ionized light that surrounds it. – Richard Germain
Richard Germain / RPS
6/9 Calm of eternity
Mountains of the Himalayas, Nepal. High mountain lake of Gosaikunda. Point of fire – 4400m. The Milky Way is the galaxy that contains the solar system, with the name describing the appearance of the galaxy from the Earth: a band of blurred light seen in the night sky formed of stars that can not be individually distinguished at the naked eye. The Milky Way is a barred spiral galaxy whose diameter varies between 150,000 and 200,000 light-years. It is estimated that it contains 100, 400 billion stars
Yevhen Samuchenko
Yevhen Samuchenko / RPS
7/9 Beetle
Beetle. Optical microscopy 5x magnification. – Viktor Sykora
Viktor Sykora / RPS
8/9 Mapping1_OxygenIb_PEM
Final major project for a Master's degree in photography at Falmouth University. Project: Mapping 1, Post-exercise Malaise. Cartography 1, focuses on the discovery of research underlying myalgic encephalomyelitis. By exploring the perspective, complexities and multidisciplinary scientific collaborations, I create images that explain, reveal and connect us consciously with the ambiguous and the unknown. – Yasmin Crawford
Yasmin Crawford / RPS
9/9 Lovell Telescope Series 1c
The Lovell telescope from the Jodrell Bank has always fascinated me since I went on a school trip. Here, I wanted to take a series of snapshots closer, more detailed and more honest than we often see. By exploring the multitude of shapes and exposing the wear of the telescope, each photo in the series is isolated or can be viewed collectively. They present in any case a powerful representation of the machine that helps humanity to understand the space and the time. – Marge Bradshaw
Marge Bradshaw / RPS
In the study, participants received growth hormone and two antidiabetic drugs. They then observed the effect on the epigenetic clock of people, in order to understand the effect on their aging.
The epigenetic clock is measured by the epigenome in the body. As people get older, chemical changes or labels add to the DNA of people and these change throughout their lives. So, by looking at these labels, one can measure a person's biological age.
The researchers actually intended to look at how the growth hormone changes the thymus tissue, which contributes to the proper functioning of the immune system and is located in the chest. It normally contracts after puberty but they hope to see if we could push it to grow back by giving the growth hormone to the participants.
It is only a secondary consideration that the researchers then checked how the drugs were changing their epigenetic clock. The study was completed when the analysis began.
Professor Horvath then examined four different measures of the epigenetic clock to understand the different ages of each patient. And he found that each of them had reversed in a significant way – so significantly that he was optimistic about the results, despite the limited number of participants.
Scientists now hope to be able to test the same effects with more people, through a controlled study, and with different age groups, different ethnicities and women.
The changes were still visible in the blood of six participants who provided their blood long after the end of the study.
Some of the drugs used in the cocktail are already being researched in order to combat age-related diseases. But the discovery of the effect of these three drugs could have major consequences on how a variety of different drugs are tested, say the scientists.
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