Geneticists have succeeded in reversing the aging process of the skin

Photo: V. Živojinović / RAS Serbia

In a unified study, the genetics of the University of Alabama successfully reversed the process of aging in the mouse by discovering what changes the cells cause wrinkling, hair loss and sedentary lifestyle. By the first therapy, the mice artificially increased their age and the abolition of this therapy led to the elimination of the regrowth of dyes and colors.

In the first part of the experiment, they used antibiotics that cause aging mitochondria in dysfunctional cells. Genetics deliberately caused aging in mice by adding antibiotics to doxycycline in food and water. Doxycycline affects the enzyme necessary for the replication of mitochondrial DNA, which depletes reserves and causes their dysfunction.

As we get older, mitochondria, a source of cellular energy, begin to lose their function. Since mitochondria produce about 90% of the energy required by living cells, the decline of their functionality promotes the development of diseases characteristic of the elderly, such as cardiovascular disease or cancer.After administration of doxycycline, the mice began to siege and loose hair, they became lethargic and lethargic. After four to eight weeks, the skin was wrinkled

The administration of doxycycline in the mouse caused the growth of cell number, abnormal hardening of the outer layer, dysfunctional hair follicles and development of the skin. ;inflammation. But as soon as they stopped giving mice to doxycycline, the animals got "fed up" because it was possible to rebuild the mitochondrial DNA.

– To our knowledge, this knowledge has never been recorded before, "says Kešav Sin, professor of genetics at UAB.

Although the elimination of doxycycline in the mouse has affected the aging process of the skin, no major changes have been observed on other organs, which may mean that mitochondria play a different role in different parts of the body.the basis for work on the Preventive and therapeutic drugs that will stimulate mitochondrial functions for anti-aging skin and hair treatments, as well as for the treatment of other diseases in which dysfunctional mitochondrial activity plays an important role. "24 Hours "

and the change in hair color by solving the problem of mitochondria dysfunction is surprising – said the son.

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