Genetics has been successful in reversing the aging process of the skin

In a unique study, the genetics of the University of Alabama succeeded in reversing the aging process in mice by discovering what changes in cells cause wrinkling, hair loss and Gray growth

In the first part of the experiment, they used an antibiotic that causes aging by making the mitochondria in the cells dysfunctional.

Geneticists deliberately induced aging in mice by causing aging they added antibiotics to doxycycline in food and water. Doxycycline affects the enzyme necessary for the replication of mitochondrial DNA, which depletes reserves and causes their dysfunction.

As we get older, mitochondria, a source of cellular energy, begin to lose their function. Since mitochondria produce about 90% of the energy required by living cells, their functional decline promotes the development of diseases characteristic of the elderly, such as cardiovascular disease or cancer. [19] After four weeks of administering doxycycline, the mice started to gray and lose their hair, they became lethargic and lethargic. After four to eight weeks, the skins were wrinkled

The use of doxycycline in mice induced an increase in the number of skin cells, an abnormal hardening of the outer layer, dysfunctional hair follicles and development of the skin. an inflammation responsible for skin changes.

The mice receive "doxycycline", the animals are "fed up" because it is possible to rebuild the mitochondrial DNA. "As far as we know, this knowledge has never been recorded before," said Kešav Sin, a professor of genetics at UAB Medical School. Although the elimination of doxycycline in mice has affected the aging process of the skin, no major changes have been observed on other organs, which may mean that mitochondria play a different role in different parts of the body. This discovery on mice could become the foundation of work on preventative and therapeutic drugs that will stimulate mitochondrial functions for anti-aging skin and hair treatments, as well as to treat other diseases where the disease can be treated. Dysfunctional mitochondrial activity plays an important role.