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Scientists from the National University of Nuclear Research "MIFI" have developed a new type of Magnetic Resonance Tomography (MRT) contrast product based on biodegradable silicon nanoparticles that can be used simultaneously for the diagnosis and treatment of oncological diseases
The Study Results have been published in the Journal of Applied Physics
MRT is a powerful method of biomedical diagnosis. which is usually used by the nuclear magnetic resonance of hydrogen atoms (protons). During the work of the tomograph, a magnetic field is created that "cuts" the protons of the hydrogen atoms into the magnetic field during the impact of radio waves
Some studies require the use of Contrast agents to increase the accuracy and informativeness of the image. The contrast signal MRT largely depends on the degree of change of the longitudinal or transverse relaxation time.
The relaxation time is the moment when the protons return to the stationary state. According to the molecules and atoms in the environment protons, which is different in healthy and diseased tissues.
In some cases, the pathology can be identified by contrast agents that locally alter the relaxation times of the diseased tissue. The combination of MRT and contrast agents enhances the ability to capture inflammation, such as tumor angiogenesis in oncology.
NINU MIFI scientists have developed a new type of contrast material based on silicon nanoparticles. According to the professor of the Institute of Biomedical Engineering Physics (IFIB) NINU MIFI and the Moscow State University "MV Lomonosov" Viktor Tymoshenko, this is an example of the development of nanotechnology – a combination of diagnostic and therapeutic methods in nanometric proportions.
Teratostatic agents for MRT are considering a combination of contrast agents and therapies to extract drugs from nano-capsules and / or
"If the MRT is widely used in the diagnosis of nano-capsules. oncology, the development of a new type of contrast product that can be used simultaneously for the milder treatment of oncological diseases is very important for modern medicine, "says Viktor Tymoshenko. Materials for nanotechnology should be nontoxic and compatible with the human organism. Another indispensable feature is "invisibility" of the immune system, otherwise they will simply be destroyed. In addition, the nanoparticles must not accumulate in the body and their surface is contaminated.
According to representatives of the Institute of Nanotechnology Institute of Biomedical Engineering (IFIB) NINU MIFI, the use of nanoparticles for the detection of malignant cells is one of the most promising. nanoparticle cancer method. These nanoparticles are not harmful to the body, however, they can, under the influence of radio waves, warm up to temperatures of about 42 oS and over (that 's what' s like). it is called hyperthermia), which ensures the local destruction of cancer cells. s, id) {
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