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University of Pittsburgh and Medical Center of the University of Pittsburgh, Pittsburgh, Pennsylvania (M.H.N., A.W.P., M.N.W.)
University of Pittsburgh, Pittsburgh, Pennsylvania (C.J.C.)
University of Alabama at Birmingham, Birmingham, Alabama (P.G.P.)
Henry Ford Health System, Detroit, Michigan (G.A.)
Ochsner Health System, New Orleans, Louisiana (G.A.P.)
School of Medicine, Indiana University, Indianapolis, Indiana (B.H.S.)
Rutgers School of Medicine Robert Wood Johnson, New Brunswick, New Jersey (A.R., M.P.W.)
Tampa General Hospital, Tampa, Florida (R.W.)
Geisinger Health, Danville, Pennsylvania (D.R.H., D.M.W.)
Weill Cornell Medicine from Cornell University, New York – Presbyterian Hospital, New York, New York (T.J.W.)
Duke University, Durham, North Carolina (J.R.P.)
Medical Center of the University of Pittsburgh, Pittsburgh, Pennsylvania; Alpert School of Medicine at Brown University, Providence, Rhode Island (E.M.)
Recognition: The authors thank the patients who participated in this study; research staff (Debbie Ashcraft, Kailey Hughes, Theresa Lingg, Ines Hamilton, Fei Chen, Amanda Styer, Michail Alevizakos, Styliani Karanika and Myrto E. Flokas), who participated in the recruitment and review of medical records; and Drs. Tom Lowery and Joseph E. Marturano for useful discussions.
Financial aid: By T2 Biosystems.
Disclosures: Dr. Clancy reports further support from T2 Biosystems during the study. Dr. Schmitt reported non-financial support from T2 Biosystems while conducting the study and T2 Biosystems' own costs outside the submitted work. Dr. Weinstein reports further support from T2 Biosystems during the study. Dr. Wolk has announced grants from Cepheid, Opgen, Streck, GenMark, La Jolla Pharmaceutical Company, Accelerate Diagnostics, DiaSorin and Roche and other support provided by OpGen, Streck, DiaSorin and Safeguard outside the submitted work. Dr. Perfect announces grants from Pfizer, Merck, Minnetronix, Amplyx and Mayne; non-financial support from Astellas Pharma; and other support from Astellas Pharma, Merck, Viamet, Minnetronix, F2G, Amplyx, Vical, Matinas and Cidara when carrying out the study. The unnamed authors here have revealed no conflict of interest. Disclosures can also be found at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M18-2772.
Disclosures of the editors: Christine Laine, MD, MPH, editor-in-chief, says his wife holds stock / asset purchase options with targeted diagnoses and therapies. Darren B. Taichman, MD, PhD, editor, says that he has no financial relationship and no interest in disclosing. Cynthia D. Mulrow, MD, MSc, Senior Editor, says she has no relationship or interest in disclosing. Jaya K. Rao, MD, MHS, Associate Editor, says she has stock / stock options at Eli Lilly and Pfizer. Catharine B. Stack, PhD, MS, associate chief statistics editor, says she owns shares in Pfizer, Johnson & Johnson and Colgate-Palmolive. Christina C. Wee, MD, MPH, Associate Editor, reports a job at Beth Israel Deaconess Medical Center. Sankey V. Williams, MD, deputy editor, says that he has no financial relationship and no interest in disclosing. Yu-Xiao Yang, MD, MSCE, deputy editor, says that he has no financial relationship nor any interest in disclosing.
Repeatable Research Statement:Study protocol: See the supplement. Statistical code: Available from Dr. Nguyen (email, [email protected]). Dataset: Relevant data are provided in tables, figures and appendices. More details are available from Dr. Nguyen (email, [email protected]).
Corresponding author: Mr. Hong Nguyen, MD, University of Pittsburgh School of Medicine, 3550 Terrace Street, Suite 871, Pittsburgh, PA 15261; email, [email protected].
Address of the current author: Drs. Nguyen and Clancy: University of Pittsburgh School of Medicine, 3550 Terrace Street, Suite 871, Pittsburgh, PA 15261.
Pasculle and Ms Wilson: Microbiology Laboratory, UPMC Presbyterian, 3477 Euler Way, Pittsburgh, PA 15213.
Dr. Pappas: University of Alabama at Birmingham, 1900 University Boulevard, 229 THT, Birmingham, AL 35294-0006.
Dr. Alangaden: Henry Ford Hospital, 2799 West Grand Boulevard, CFP 316, Detroit, MI 48202.
Dr. Pankey: Ochsner Health System, 1514 Jefferson Highway, New Orleans, LA 70121.
Dr. Schmitt: Indiana University School of Medicine, 350 West 11th Street, Room 6027D, Indianapolis, IN 46202.
Drs. Rasool and Weinstein: Robert Wood Johnson Rutgers School of Medicine, 125 Patterson Street, New Brunswick, NJ 08903.
Drs. Hernandez and Wolk: Geisinger Health, 100 North Academy Avenue, Danville, PA 17822.
Dr. Walsh: Weill Cornell Medicine of Cornell University, New York – Presbyterian Hospital, 1300 York Avenue, Room A-421, New York, NY 10065.
Dr. Perfect: Duke University Medical Center, Hanes House, Trent Drive, Durham, NC 27710.
Dr. Mylonakis: Division of Infectious Diseases, Rhode Island Hospital, 593 Eddy Street, Physician Office Building, 3rd Floor, Suite 328/330, Providence, RI 02903.
Author contributions: Design and Design: Mr. H. Nguyen, C. J. Clancy, P. G. Pappas, R. Widen, D. Wolk.
Data Analysis and Interpretation: M.H. Nguyen, C.J Clancy, A.W. Pasculle, G. Alangaden, G.A. Pankey, B.H. Schmitt, A. Rasool, M. P. Weinstein, D. R. Hernandez, J. R. Perfect, E. Mylonakis.
Article Writing: M.H. Nguyen, C.J. Clancy, G. Alangaden, Pankey G.A., B.H. Schmitt, E. Mylonakis.
Critical Review of the Article for Significant Intellectual Content: Mr. H. Nguyen, C. J. Clancy, P. G. Pappas, B. H. Schmitt, M. P. Weinstein, D. R. Hernandez, T. J. Walsh, E. Mylonakis.
Final approval of the article: Mr. H. Nguyen, CJ Clancy, AW Pasculle, PG Pappas, G. Alangaden, Pankey GA, BH Schmitt, A. Rasool, MP Weinstein, DR Hernandez, DM Wolk, TJ Walsh, JR Perfect, MN Wilson, E. Mylonakis.
Supply of study materials or patients: Mr. H. Nguyen, A. W. Pasculle, P. G. Pappas, G. Alangaden, G. A. Pankey, B. H. Schmitt, M. P. Weinstein, R. Widen, D. R. Hernandez, E. Mylonakis.
Statistical Expertise: Mr. H. Nguyen, C. J. Clancy.
Administrative, technical or logistical assistance: A. W. Pasculle, R. Widen, D. R. Hernandez, E. Mylonakis.
Collection and assembly of data: M. H. Nguyen, A. W. Pasculle, G. A. Pankey, B. H. Schmitt, A. Rasool, M. P. Weinstein, R. Widen, D. R. Hernandez, M. N. Wilson, E. Mylonakis.
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