The use of "high risk" antibiotics in hospitals can increase the risk of C. Diff

The use of high-risk antibiotics in hospitals, such as cephalosporins, fluoroquinolones, carbapenems and lincosamides, was associated with an increased risk of Clostridioides difficult in hospitals, the researchers found.

After adjusting for confounders, for each 100-day increase in the use of high-risk antibiotics per 1,000 days, risk of It's hard the infection increased by 12% (RR 1.12, 95% CI 1.05-1.21), said L. Clifford McDonald, MD, of the CDC, and colleagues, writing Infection control and hospital epidemiology, the journal of the Society for Healthcare Epidemiology of America.

"This highlights the importance of ongoing monitoring of the use of antibiotics in hospitals for patient safety with regard to the effect of antibiotics on It's hard infections, "McDonald said in a statement.

The authors noted that overconsumption of antibiotics is now considered a major factor in It's hard infections, particularly previous research that revealed that almost half of hospitalized patients had received an antibiotic and that 30% of these antibiotics were potentially useless, they said.

"In addition to the direct effects of antibiotics on[[[[It's hard infection]risk, antibiotics intervene in the transport It's hard spores by asymptomatic carriers … and are sources of transmission likely to increase the[[[[It's hard infection]in acute care facilities, "wrote the authors.

Researchers examined data from 171 hospitals in 2016-17 via the BD Institute's research database. They defined 4 classes of antibiotics as high risk, based on previous research and guidelines for specific antibiotics to be treated. It's hard infection, they said: second, third and fourth generation cephalosporins, as well as fluoroquinolones, carbapenems and lincosamides. The authors noted that the piperacillin / tazobactam ratio was also evaluated, with some studies considering it as "medium risk". It's hard infection.

Of the 171 study sites, the majority were non-university hospitals (61%) and about half were located in the southern United States. Cephalosporins accounted for about half of the most commonly used antibiotics, followed by fluoroquinolones (31.6%). There was a significant correlation between the use of high-risk antibiotics and It's hard infection, with a higher correlation between the two observed in teaching hospitals compared to non-university hospitals.

The authors found that the overall pool associated with the hospital It's hard The infection rate was 35 per 10,000 admissions, with a median of 33 per 10,000 in 171 hospitals. It is not surprising that the factors associated with higher rates of It's hard The infection included increased use of high-risk antibiotics, a larger proportion of patients older than 65, a longer average length of stay and a higher use of inhibitors of proton pump.

Data limitations include the fact that the study is not representative of all US hospitals and that as an ecological study, it does not describe cause-and-effect relationships.

McDonald said in a statement that in the future, it will be important to examine the effects of antibiotic use on It's hard infection and antibiotic resistance together rather than separately.

"An institution may use the use and antibiotic resistance module of the national health care safety net and interpret the results with the help of the standard antibiotic administration ratio ( SAAR) to better understand how antibiotics are used and to identify areas for improvement, "he said.

2019-09-16T18: 00: 00-0400