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Every day, scientists work to find a cure for cancer. It's not that you need a reminder, but cancer is defined as the process by which abnormal cells begin to multiply, old cells remain and new useless cells appear. These deformed cells often form tumors that can spread, making their treatment difficult.
Researchers at Mount Sinai Hospital have come up with a new method of cancer immunotherapy that teaches the immune system to destroy tumor cells in the body.
In the new study published in Nature Medicine, Scientists have injected immune stimulants into the tumor to stimulate the immune system. They found that these stimulants recruited and instructed dendritic cells and T cells, two important immune systems that kill cancer cells and maintain healthy cells.
During this process, the immune cells have learned which cells to kill and could continue to kill them throughout the body. They tested what they call an "in situ vaccination" in patients with advanced lymphoma and found that it was effective.
Even more effective was when this approach was combined with the blocking of checkpoints, a current immunotherapy option in which a drug blocks the proteins that inhibit the destruction of cancer cells.
"This method could also increase the success of other immunotherapies such as blocking checkpoints," said lead author Joshua Brody, MD, director of the Lymphoma Immunotherapy Program. Tisch Institute Against Cancer at the Icahn School of Medicine at Mount Sinai Hospital.
The success of this combined immunotherapy approach has resulted in new clinical trials for breast, head and neck cancer, in which the in situ vaccine will be used in conjunction with drugs for the blocking of control.
The researchers hope that the combination of these therapies could be particularly effective for several types of cancers. Since cancer is the leading cause of death in the world, we can not think of better news.
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