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A new study suggests that there is hope that aspirin – one of the most widely used drugs in the world – can help treat some aspects of the disease. Devastating Alzheimer's.
Scientists have discovered that aspirin works with a specific non-atomic mechanism in the brain that prevents amyloid plaques and sticky protein drops around brain cells, which would be the leading cause of the disease. 39, Alzheimer's, according to a recent study. On the mice.
Experiments conducted in mice in the study showed that aspirin stimulates the ability of lysosomes (which are somewhat similar to cells that treat and recycle cell debris) to eliminate amyloid plaques or to prevent them from forming. "Aspirin should have the same effect on Alzheimer's disease that affects humans as well on the other side of the mouse," said researchers who published their findings on July 2. in the journal Neuroscience.
Alzheimer's disease is the most common form of dementia, an ascending cerebral disease that affects nearly six million Americans, the sixth leading cause of death among all adults in the United States, according to the Centers for Disease Control and Prevention.
There is no cure, and the drugs have also achieved very limited success in slowing the progression of the disease.
Aspirin, also known as acetylsalicylic acid, is a reasonably priced drug that has been used safely at low doses for a century, despite the possible gastric irritation and the low risk of intestinal bleeding.
Many adults take a small dose of aspirin each day as a mild blood solvent to prevent heart attacks.
In fact, in a large-scale study on aspirin and heart health, aspirin has also been found to reduce the risk of Alzheimer's disease even moderately.
In March, Chinese researchers metastatically analyzed (analysis of research results by incorporating the results of several independent research) in the journal Frontiers in Aging neuroscience by examining 18 population-level studies and found that the results of the study were not comparable. Regular use of anti- (NSAIDs), including aspirin, is associated with a lower risk of developing Alzheimer's disease averaging 20%.
Researchers at the Rush University Medical Center in Chicago have prepared essays requiring aspirin for mice with Alzheimer's and applied aspirin directly to rat brain brain cells. "Both approaches – inside the body and in the laboratory – seem to prevent or reverse the biological signs of Alzheimer's disease," says Kalibada Bahan, author of the main study and professor of neuroscience at Rush University.
Bahan explains: "Aspirin activates a cellular future called PPARα, which in turn regulates the TFEB protein – the main regulator of lysosomal activity.
In short, aspirin helps cells to clear cellular debris, including proteins forming amyloid plaques.
Bahan completed Live Science review: "We expect to see the same results in human brain cells."
In fact, other drugs such as gemfibrozil, which lowers triglycerides in the blood (also known as Lopid), control other TFEB proteins, but aspirin is safe enough to be available without a prescription and has fewer side effects. "The recent study offers a great mechanical explanation for the protective effects of aspirin at the cellular level and animal models," said Rajini Rao, professor of physiology at l & # 39; Kingdom Johns Hopkins versity in Baltimore who has not been involved in research.
However, she noted that the study did not determine whether the degree of improvement in the amyloid removal would result in better brain function.
The results of epidemiological studies on the use of aspirin for dementia are also very different, but Rao told Live Science magazine, while there are indications of protection, but some studies fail to confirm this.
Unfortunately, this is the case with all the drugs used in Alzheimer's disease trials and over 99% of them have failed, which is why research on Alzheimer's disease and more than 99% of them have failed, which is why research on the Alzheimer's disease is a particular challenge.
Although aspirin is relatively safe, it is at risk when used daily, and should not be used as an unfounded means of treating or preventing Alzheimer's disease " , Bahan said.Also stimulates lysosomal activity.
PPARÎ ± receptors must exist, so that aspirin does not affect any patient with insufficient PPARÎ ± receptors, which explains the contradictory results. of the study at the level of the population (19659024)
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