"Trojan horse" to deal with deadly diseases!

Researchers have developed a powerful "Trojan horse" that can deceive superhuman bacteria by binding to the iron molecules they need to live and grow.

Once the drug called cefiderocol enters the bacterial cell, it can destroy it from within, according to researchers from Shionogi, New Jersey, published in a prestigious medical journal.

"Cefiderocol acts as a Trojan horse and uses a new mechanism to enter the cell, taking advantage of the iron's need for bacteria to survive," said Dr. Simon Portsmouth, head of the Lancet Study Group, who writes: "During an acute infection, one of our innate immune responses In response, bacteria increase iron intake."

"The Cefiderocol binds the iron and passes through the excess outer membrane through the bacteria's iron transport system, so that the iron channels allow the drug to bypass the bacteria channels even though the circulation pumps are developed."

Experiments were conducted on 452 hospitalized patients with acute infections for two weeks.

Two-thirds of patients taking the drug developed three times a day, while others received another antibiotic called imipenem-cilastatin. The new treatment had the same potent antibiotic efficacy.

Antibiotic resistance is considered the biggest threat to modern medicine, with warnings that drug-resistant infections will kill more people with cancer and diabetes by mid-century.

The excessive use of antibiotics has resulted in the development of bacteria to fight against conventional drugs, resulting in the loss of much of its strength against infections.

Further research is now needed to test the drug against the most virulent antibiotic-resistant bacteria.

Source: Daily Mail