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The largest study to date on the genetic composition of helminths has shown hundreds of new evidence on how to invade the human body, avoid its immune system and cause disease.
The results suggest potential treatments to get rid of these worms to combat some of the most neglected tropical diseases, including river blindness, schistosomiasis and ancelostomes, which affect about one billion people worldwide.
"Parasitic worms are some of our oldest enemies and have evolved over millions of years to gain considerable experience in manipulating the immune system," said Mikdunka Mitreva of the McDonnell Institute of Genome. University of Washington.
"The results of this study will shed light on parasite life and better understand how the human immune system is used and controlled," she said.
Physical disability and stunting
Parasitic infections can last for many years and cause severe pain, physical disability, retarded growth of children, and social stigma associated with a malformation.
The drugs they currently treat, including drugs developed by Sanofi and Johnson & Johnson, may have little effect, but the scope of the drugs that process the cuts is still limited.
In an attempt to improve drug development and understand how worms encroach on the human and animal body and animals, the research team compared the genetic map of 81 types of round and flat worms, including 45 have never been genetically modified.
The analysis uncovered nearly a million new genes belonging to thousands of new genetic families and identified many potential drugs.
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