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Fighting cancer means killing cancer cells, but oncologists know that it is also important to stop the movement of cancer cells before they spread throughout the body.
A new study published in Nature Communications shows that cancer cells can be frozen and killed wherever they are.
Raymond Berrgan, head of the Division of Hematology and Oncology and Professor of Medicine at OHSU, said, "Most cancer treatment methods are aimed today. to kill cancer. " Move around the body. "For most cancers, such as breast cancer, prostate, lungs, colon and other types, if detected early," says Pergan, who is also deputy director of medical tumors at the # OHSU Knight Cancer Institute and Director of the OHSU Bergan Laboratory for Basic Research. When a small block is in the member), and has not yet spread, you will live.
And in a year, if you discover late after the cancer has spread through your body, you will die. "
" Movement is key, they are the difference between black and white, night and day, and if cancer cells spread through your body, they will kill you, we can treat them, but that will cost you life. "
For this reason, studying the movement of cancer cells (movement capacity) has been at the center of his group's research for several decades.
Stop Cancer Cell Traffic:
In 2011, Bergan and his team took a new approach to their research by collaborating with chemists to discover a new drug that would inhibit the movement of cancer cells. KBU2046, a compound that inhibits the ability of the cell to move in four models of different human breast cancer cells: breast cancer, prostate, colon and lung. "We used chemistry to explore biology, to give us an effective drug that would only inhibit the movement of cancer cells and do nothing else. This fundamental shift in logic will lead us to do everything what we want, "said Bergan.
Purification of Drugs:
Bergan explained that the filtration process of the Special Pharmacopoeia was a process of purification.
"We started using a chemical that prevented the cells from moving, then we refined the chemical so that it did an ideal job of stopping the cells without any side effects" he says. All medications have side effects, so you should seek as much as possible of the highest quality drugs, and this medication does it. "
The main key of this drug is the use of heat shock proteins (cell cleansers).
The way the drug acts is to bind these cleaning proteins to stop the movement of the cell, but it has no other effect on these proteins, as it is an unusual and rare way that it took us years to discover.
"Nobody would fund us at first, and we looked differently during the treatment of cancer. "
Next Step: Drug Testing in Humans:
In the end, Gordon says that the purpose of this research is essentially to find a new cure for human benefit. "The hope of this research is that we are working to develop a therapeutic approach that can help manage the early stage of the disease to prevent patients from reaching the irreversible stage (intractable ) ", did he
He quickly noticed that this work had not been tested on humans, that it would take time and money and that it would take about two years for the team to have the best team, and would need $ 5 million.
They are currently raising funds to conduct IND studies (a new testable drug), a condition for clinical testing of an unsupported drug, a product certified for a new presentation, or a new group of patients. "Our ultimate goal is to be able to tell a woman with breast cancer: Take this pill and your cancer will not spread through your body, the same for prostate cancer patients, lung and colon.
This treatment is very effective in the laboratory up to now against four types of cancer (breast, colon, lung and prostate cancer), and our goal is to steer this treatment as a test for humans. "
Bergan said that his team felt lucky to have the opportunity to carry out this difficult research at the OHSU Knight Cancer Institute, an institute dedicated to new approaches to detection and detection. Cancer Treatment.
"What early detection is trying to do is detect early lethal damage, and the cancer is deadly because it's moving. This drug is designed to stop this movement," Pergan says.
This research was supported by the Department of Defense and the Veterans Administration
- Translation by: Uday Baksrawy
- Proofreading: Tasnim Al-Munajjid
- Editor: Zaid Abu-Rab
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