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London: Scientists have discovered why many people have a hard time keeping their weight as they grow older, even though they do not eat more or do less exercise than before.
The study, published in the journal Nature Medicine, revealed that lipid turnover in adipose tissue – the rate of elimination of lipids or fat cells in fat cells – decreases during aging and facilitates the weight gain.
Researchers at the Karolinska Institutet in Sweden studied fat cells in 54 men and women over an average of 13 years.
During this period, all subjects, whether gaining weight or not, showed a decrease in lipid turnover in adipose tissue.
According to a study conducted in collaboration with researchers from the University of Uppsala in Sweden and the University of Lyon in France, those who did not compensate for this by consuming fewer calories had gained weight from 20% on average.
The researchers also examined lipid shuffling in 41 women undergoing bariatric surgery, and explained how the rate of lipid reversal affected their ability to maintain weight four to seven years after surgery.
The results showed that only those who had a low rate before the operation were able to increase their lipid turnover and maintain their weight loss.
Researchers believe that these people may have more opportunities to increase their lipid turnover than those who have already undergone high-level surgery.
"The results indicate for the first time that the processes of our adipose tissue regulate changes in body weight during aging independently of other factors," said Peter Arner, professor at the Karolinska Institutet.
"This could open up new ways to treat obesity," Arner said.
Previous studies have shown that one way to accelerate lipid turnover in adipose tissue is to do exercise.
The new research supports this notion and further indicates that the long-term results of weight loss surgery would improve if combined with increased physical activity, the researchers said.
"Obesity and diseases associated with obesity have become a global problem," said Kirsty Spalding, of the Karolinska Institute.
"Understanding the dynamics of lipids and what regulates the size of fat in humans has never been more relevant," said Spalding.
This story was published from a news agency thread without text modification. Only the title has been changed.
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