Home / Health / A syringe in a robotic pill completes a successful human trial / Boing Boing

A syringe in a robotic pill completes a successful human trial / Boing Boing

RaniPill is another syringe that you can swallow to administer medications in the blood of the interior. It is triggered by an interesting and complex mechanism involving a chemical reaction that inflates a tiny polymer balloon to push the needle into the intestinal wall. Rani Therapeutics has successfully completed a clinical trial of 20 people using a white pill. IEEE spectrum:

Working from the outside to the inside, RaniPill is a special coating that protects the pill from the acidic juices in the stomach. Then, when the pill is pushed into the intestines and the pH rises to about 6.5, the coating dissolves to reveal a deflated biocompatible polymer balloon.

When exposed to the intestinal environment, a tiny pinch point composed of sugar inside the balloon dissolves, causing the mixing of two chemicals trapped on the other hand. other of the pinch point and the production of carbon dioxide. This gas inflates the balloon and the pressure of the balloon pushes a soluble micro-needle filled with a drug of choice into the wall of the intestine. The human intestines are devoid of painful receptors, which makes the micro-shooting pain-free.

According to animal studies, however, the intestinal wall contains many blood vessels. The drug is quickly absorbed into the blood. The needle itself dissolves …

Participants spent the remainder of the balloon after 1 to 4 days.

(Founder Mir) Imran calls this device a robot although it has no electrical parts or metal. "Even if he does not have a brain or electronics, he [works through] an interaction between materials science and body chemistry, "says Imran. "It performs a single mechanical function autonomously."

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David Pescovitz

David Pescovitz is the co-publisher of Boing Boing. On Instagram he is @pesco.


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