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Chlordecone: in utero exposure also affects 3rd generation
Insecticide used in the West Indies from 1973 to 1993, chlordecone impacts quantity and quality sperm when exposure to this toxin was in utero. A phenomenon identified in the mouse up to the third generation
During the development of the embryo, exposure of the mother to endocrine disruptors can alter the reproductive function of the young. What about placental barrier is known in a direct exposure for the first and second generation (directly from the gametes of the first). So far, the indirect effect of exposure to chlordecone in utero, on the third generation, has yet to be evaluated
Inserm * scientists have exposed " oral gestational mice to a daily dose of chlordecone known not to induce adverse effects in this species in adulthood (100 μg per kg of body weight) ". The exhibition took place from " 6th to 15th day embryonic, critical window for the transmission of epigenetic information to subsequent generations but also vulnerability to the development of germ cells ."
] Fewer spermatozoa
Results, chlordecone would have " transgenerational effects on sperm production. The entire germ line in the male is affected either quantitatively or qualitatively and after two generations "says Fatima Smagulova, researcher at Inserm, scientific leader of this work and a ATIP team / Future. Evidence that the impact of chlordecone is not only observed during direct exposure on the 1st and 2nd generations, but also indirectly on the 3rd generation. In detail, in utero exposure to chlordecone causes in males:
A decrease in the number of germinal stem cells (at the origin of spermatozoa);
An impairment of their differentiation; [19659009] A decrease in the number of mature spermatozoa.
Results concerning in utero exposure exclusively therefore. Indeed, " levels of environmental exposure to chlordecone, which populations are currently facing, are not likely to cause changes in sperm characteristics, when exposure occurs in adulthood
To date, researchers do not know if this risk also applies to humans.
* University of Rennes, EHESP, Inserm, Irset (Institute for Health Research, Environment and work) – UMR_S 1085, Rennes
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