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A text by Kim Vermette
The discovery of Dr. St-Arnaud and his team could give hope to people who suffer from osteoporosis, glbad bone disease and the elderly, who are more prone to fracture
When absorbing vitamin D, the human body transforms it in two stages to obtain its hormonal properties. From these stages is created the molecule 24,25 (OH) 2 that specialists considered previously inactive.
It took 15 years of work to Dr. St-Arnaud to reach the conclusion that this residue of degradation actually had other virtues.
It has been found that not only does this metabolite have a biological activity to optimize the repair of bone fractures, but it has also been discovered the mechanism by which the molecule works
explains Dr. St-Arnaud
The Montreal researcher and his team performed a host of tests on mice.
Fracture repair was examined in these animals. there, and we realized that the structure that helps repair the bone, called bone callus, was always smaller, more fragile. If dihydroxyvitamin D were given back, this deficiency was corrected
he explains
A glimmer of hope
If a treatment is not close to being offered, it does not the fact remains that the news gives hope to people like Khadidja Chougui.
The 25-year-old woman is suffering from type 3 osteogenesis imperfecta, also known as the disease of glbad bones.
I had more than a hundred fractures, I do not count anymore. If a child had the miracle solution to heal faster and more effectively, I really think it could improve his quality of life.
The slightest jolt, I fractured myself. It was made that my parents dared not take me in their arms, but through a board not to handle me wrongly.
A discovery « extraordinary "
For my team and me, it's extraordinary. We worked so long and there was so much skepticism about our work. When we presented intermediate results, we were told: "as long as we do not know how it works, we do not believe it, it's in the realm of anecdote". So we made sure we understood everything before publishing this.
, says Dr. St-Arnaud
The next step will be to conduct clinical trials on patients at Shriners Hospital for Children. Difficult for Dr. St-Arnaud to give a deadline, but already, he allows himself to dream big. My wildest dreams would be that the molecule be given as a probiotic or as a vitamin supplement to act as a prophylaxis.
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