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A study of bacteria in the intestine has highlighted differences between hypertensive and depressed individuals, according to a preliminary study presented at the 2019 Hypertension Scientific Sessions of the American Heart Association.
"People are" meta-organisms "made up of about equal numbers of human cells and bacteria.The intestinal ecology of bacteria interacts with our body physiology and our brain, which can bring some people to develop high blood pressure and depression, "said Bruce R. Stevens. , Ph.D., lead author of the study and professor of physiology and functional genomics, medicine and psychiatry at the University of Florida's School of Medicine in Gainesville, Florida. "In the future, health professionals could target your gut to prevent, diagnose and selectively treat different forms of hypertension."
Stevens said this research could reveal treatment approaches likely to improve outcomes in people with treatment-resistant hypertension. Nearly 20% of hypertensive patients do not respond well to treatment, even with multiple medications.
The researchers isolated DNA (deoxyribonucleic acid, carrier of genetic information) from intestinal bacteria obtained from stool samples of 105 volunteers. They used a new technique using artificial intelligence software to analyze the bacterium, which revealed four distinct types of bacterial genes and signature molecules. Surprisingly, researchers have discovered unique patterns of bacteria from people suffering from 1) high blood pressure and depression; 2) high blood pressure without depression; 3) depression with healthy blood pressure; or 4) healthy subjects without depression or hypertension.
Stevens said the findings suggest different medical mechanisms of high blood pressure that correlate with the signature molecules produced by intestinal bacteria. These molecules are thought to have an impact on the cardiovascular system, metabolism, hormones and the nervous system.
"We believe we have discovered new forms of hypertension:" depressive hypertension "(hypertension with depression), which may be a completely different disease from" non-depressive hypertension "(hypertension without depression) , which are each different from "non-hypertensive depression," Stevens said.
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Material provided by American Heart Association. Note: Content can be changed for style and length.
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