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According to a new study, intestinal bacteria can alter the cells' response to insulin and thus contribute to type 2 diabetes.
The study has shown that the intestinal microbiota of people with type 2 diabetes who have never been treated with a treatment may be linked to a different metabolism of histidine, an amino acid, which originates from mainly from food.
This leads to the formation of imidazole propionate, a substance that impairs the ability of cells to respond to insulin. Therefore, reducing the amount of imidazole propionate produced by bacteria could provide a new way to treat patients with such a disease.
"This substance does not cause all type 2 diabetes, but our working hypothesis is that there are subpopulations of patients likely to benefit from a diet change or gut microbiota lowering the rates of imidazole propionate, "said Fredrik Backhed, Professor at University of Gothenburg, Sweden.
For the study, published in the journal Cell, the research team involved 649 participants.
They used stool samples and found that the microbiota of people with type 2 diabetes produced imidazole propionate when histidine was added. However, this mechanism was not found in control subjects without diabetes.
"Our results clearly show how important the interaction between gut microbiota and diet is to understand our metabolism, both for health and disease," said Backhed.
The result also shows that the intestinal bacteria of different individuals can lead to the production of totally different substances that can have very specific effects on the body, "he noted.
–IANS
pb / vc / mag / mr
(This story has not been changed by Business Standard staff and is generated automatically from a syndicated feed.)
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