The use of steroids during cardiac bypass did not reduce the risk of serious kidney damage

The use of steroids during cardiopulmonary bypbad did not reduce the risk of acute kidney injury in people at increased risk of death, according to a study conducted in 18 countries and published in CMAJ (Journal of the Canadian Medical Association).

The multi-site randomized controlled trial, funded by the Canadian Institutes of Health Research, included patients from: Canada, China, Czech Republic, India, Colombia, Australia, Italy, Iran, United States, Greece, Brazil, Austria, Belgium and Hong Kong. , Argentina, Chile and Ireland, which broadens the scope of the study results.

Approximately one-fifth of the world's millions of bypbad surgeries worldwide result in acute kidney damage, which in its most severe forms greatly increases the risk of death and the need for dialysis treatments essential for survival. Bridging surgery can trigger widespread inflammation, which is thought to be the main cause of kidney damage. Previous studies have suggested that steroids could help reduce inflammation and acute kidney damage.

"The administration of steroids to prevent inflammation during surgery has not reduced the risk of acute kidney injury in people with a moderate to high risk of adverse effects," he said. the author, Dr. Amit Garg, scientist at the Lawson Health Research Institute and professor at the Schulich School of Medicine. And Dentistry, Western University, London, Ontario, Canada.

The study included 7286 patients, about half of whom (3647) had been randomized to receive steroids and the remaining 3639 had a placebo. The rate of acute kidney injury was similar in both groups.

"Given the wide range of countries and populations represented in the study, these findings argue in favor of a reduction in the use of steroids as an effective method of preventing the complications of diabetes." 39, inflammation during a bypbad, "said Dr. Garg.

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Journal of the Canadian Medical Association