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It has been shown that diabetes mellitus doubles the risk of developing pancreatic cancer. Sulfone triamcinolone and insulin increased the risk of pancreatic cancer, while metformin, thiazolidinediones and DPP-4 inhibitors decreased the risk of pancreatic cancer.
According to the Korean Food Communication Forum (KOFRUM) of April 4, researchers of 8589 pancreatic cancer patients who participated in the national cancer registration project until 2015 badyzed the relationship between diabetes and pancreatic cancer, it turned out. The results of this study (Impact of Diabetes and Diabetes Treatment on Pancreatic Cancer Risk: A Population Study of Korea as a Whole) were published in the latest issue of Scientific Reports, the journal's sister journal. Nature
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Of the 397.9394 non-diabetic individuals diagnosed in this study, 5673 were diagnosed with pancreatic cancer (incidence: 0.36%). Of the 966,492 diabetic patients, 2916 had pancreatic cancer (incidence 0.78%). The incidence of pancreatic cancer in diabetic patients is more than twice that of the general population.
The choice of diabetes medications has a big impact on the incidence of pancreatic cancer.
Metformin, thiazolidinedione, and antidiabetic agents based on DPP-4 inhibitors reduce the risk of pancreatic cancer by 14%, 18%, and 43%, respectively. In contrast, sulfonemia and insulin increased the risk of developing pancreatic cancer by 1.7-fold and 2.9-fold respectively (compared to those who did not use a cure for diabetes ).
"The risk of pancreatic cancer in patients on metformin plus thiazolidinediones, metformin and DPP-4 inhibitors is lower than in patients taking metformin alone," report the researchers. "Diabetes is a risk factor for pancreatic cancer But the study concluded that changing the treatment could significantly reduce the risk of developing pancreatic cancer."
According to the latest edition of the Journal of the National Cancer Institute, African-Americans were three times more likely to be diagnosed with pancreatic cancer within three years of the diagnosis of diabetes than those without diabetes. And 4 times for Latin Americans. The medical profession says it's safe to suspect pancreatic cancer if it's older and has diabetes over the past year.
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