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| ▲ This figure shows the resolving power of predatory bacteria in the biomembrane (green dot) of Staphylococcus. It can be confirmed that the biomembrane is degraded after the predominant bacteria have been treated. | ||
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| ▲ The results of the number of predatory bacteria making proteases using biomembranes of Staphylococcus aureus | ||
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| Analysis of the transcriptome of predatory bacteria. The RNA transcript of the predatory bacteria was isolated and badyzed (red dashed line) in the presence of the staphylococcal biomembrane, indicating that the predatory bacteria found in the previous experiment had acquired nutrients and were engaged in predation activity (line black, dashed black) Similar to the measured values. This shows that predatory bacteria can use Staphylococcus halo biofilm as a nutrient. | ||
Research shows that predatory bacteria can destroy the "biofilm" of pathogens. "Bello", a bacterium that is effective at eliminating biofilms that cause chronic diseases, should play a new role.
The team of Professor Robert J. Mitchell at UNIST (Department of Biomedical Sciences) stated that BALO (Bdellovibrio and Like Organism) removes biofilms from gram-positive bacteria and makes them nutrients .
Bacteria are clbadified as Gram Positive and Gram-negative Bacillus bacteria by Gram stain. Gram-positive bacteria are purplish bacteria when stained with Gram stain.
Gram-negative bacillus is a germ-negative bacterium that is stained with red bacteria when stained with Gram-negative Bacillus Gram stain (Gram-negative Bacillus). Salmonella bacteria, dysentery, typhoid, E. coli, cholera, gonorrhea, meningococcus and spirochaetes are typical examples
Bello is a bacterium that consumes Gram-negative bacteria. Bello is harmless to the human body while eating pathogenic bacteria harmful to our body, and it attracts attention as 'living antibiotics'.
Mitchell's team began to study the interaction between Gram-positive bacteria and Bello, filling gaps in the Bello trait.
As a result, the predatory bacterium, Bdellovibrio Bacteriovorus HD100 (Bdellovibrio Bacteriovorus HD100), degrades the biofilms formed by staphylococci through proteolytic enzymes. And to use it as a nutrient.
When our bodies are injured or infected, bacteria form a biofilm, forming a group of bacteria. Biofilms composed of proteins, lipids, etc., increase antibiotic resistance and inhibit the effects of the drug, leading to chronic diseases. Therefore, it is essential to remove this biofilm for the effective treatment of infectious diseases.
First author, Dr. Hansol UNIST said: "The decomposition of the biofilm is very useful for the treatment of infectious diseases because it can increase the antibiotic and drug effect. "Until now, Bello is known to be able to remove their biofilm naturally eating Gram-negative bacteria, and this study has shown that it can remove biofilm from Gram bacteria." -positive. " [19659011] The researchers hope that the biofilm degradation effect of Gram-positive bacteria will be verified and that the range of applications of bello in the treatment of infections will be expanded.
Robert Mitchell, professor of biosciences and biotechnology, said, "The biofilm of bacteria is an infection in the human body. In addition, it can be found in everyday life, such as water pipes and water tanks. "By using the biodegradable effect of Bello, the biofilm can be removed in an environmentally friendly way, so that there will be many fields to use in the future."
Meanwhile, the present study was carried out on May 31, 2009, online edition of the ISME Journal, "Bdellovibrio bacteriovorus HD100, a Gram-negative bacteria predator, energetically benefits from biofilms of Staphylococcus aureus without predation" (UNIST, 1st author), Mohammed Dwidar (OIST, correspondent) Robert Mitchell (R obert J. Mitchell, UNIST, Correspondent).
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