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Prof. Song Ji-hwan of the Department of Biological Sciences, Daehan University of Science, produced Induced Pluripotent Stem Cells (iPSCs), which could theoretically be transplanted in 41.7% of Koreans without immune rejection
. (19659002) Professor Song (Department of Life Sciences, Department of Biosciences and Biotechnology, Chungbuk Cha Hospital and Professor Huh Ji Young, Department of Biochemistry, Chungbuk National University) (Haplotype HLA) Screening of the antigen haplotypes of human leukocytes, we selected 10 cord blood samples with the most common haplotypes among Koreans, and then produced the induced pluripotent stem cell line (iPSC)
. Making iPSCs as somatic cells of patients is also less likely to cause immune rejection.
On the other hand, using the iPSC created by Professor Song, the cost and time can be significantly reduced.
The ten cell lines produced by Professor Song showed that most HLA haplotypes were able to differentiate into several cell types when the HLA haplotype was paired
HLA is an antigen that differentiates between my tissues and other tissues, and serious rejection occurs when transplanting organs or cells of a different type. 19659002] The type of HLA is determined by the haplotype, which means a set of alleles in each locus on a chromosome (where the gene occupies a chromosomal or chromosomal map). [19659002] Since HLA types are determined by a father-side haplotype and a mother-side haplotype, the probability that the HLA type corresponds to the brother is one-quarter.
Professor Song also compared and badyzed HLA data around the world through an international collaborative study, which uncovered the Korean cell lines from this study in Japan and China.
In fact, of the top ten cell lines in Korea, there were six in Japan and five in China.
On this basis, Professor Song insists on the need for international cooperation in this area. Currently, Professor Song is Director of the Global Alliance for iPSC Therapies (GAiT) for the clinical clbad iPSC Therapeutics and leads international cooperation with Korea and Asia.
International Consortium, iPSC
Prof. Song Ji-hwan said, "With this research, we can dramatically reduce the time and cost of custom cells using inducible pluripotent stem cells." of the similarity of HLA haplotypes, cooperation with various countries, such as Japan, China, the United States and the United Kingdom, will be more useful at the international level. "
(Ministry of Health and Good -be) and the Korean Institute of Development of the Health Industry (HI15C3042).
Journalist Park Ki Taek [email protected]
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