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Graphene has made various attempts not only in the field of electronic materials but also in the biomedical field.
The results of this study are as follows: The results of this study are as follows: First, the results of this study are as follows: It was published in the July issue of "Scientific Reports", the fraternity of the journal Nature. "Graphene oxide polarizes iNKT cells for TGFβ production and attenuates inflammation in an iNKT-mediated cell sepsis model," which was published online, 19659004] Sepsis refers to the syndrome systemic inflammatory response that occurs when the blood is infected with microorganisms (viruses, bacteria, etc.). Professor Hong Seokman and Professor Hong Seok Rin of the team observed the regulation of graphene oxide on the immunological activity of glycolipid, one of the septic inducers of Gram-positive bacteria. positive. In this process, we investigated the immunological properties of graphene oxide using α-GalCer, one of the glycolipid series
Through this study, we found that the oxide of Graphene Inhibits Invariant T Natural Killer (iNKT) Differentiation induced in an anti-inflammatory phenotype that secretes bad-specific TGFβ cytokine, and secondly reduces the incidence of cytokine storms that overexpress NK cells, γδ T cells and inflammatory cytokines of macrophages.
There is currently no FDA approved treatment for sepsis, which is a key element in the suppression of sepsis. Gram-positive bacteria such as Streptococcus pneumoniae, Escherichia coli and Enterobacteriaceae cause sepsis in newborns, infants under 4 years of age or the elderly.The bacteria responsible for sepsis are 50% Gram-positive bacteria and 30% % of Gram-negative bacteria. The glycolipid-based antigens, which are cellular components of these bacteria, are taken by dendritic cells or macrophages and stimulated with iNKT cells on CD1d, a molecule with antigen, to secrete inflammatory cytokines, causing thus inflammation such as liver damage and sepsis.
iNKT cells have innate immune characteristics that are rapidly activated in response to the glycolipid antigens presented by CD1d, and inhibit inflammatory cytokines such as IFNγ and TNFα and anti-inflammatory cytokines such as lymphatic cytokines. IL10 and TGFβ. It can secrete all the film and can act as a regulator in the inflammatory response. Therefore, the phenotypic regulation of iNKT cells, which influence the initial immune response in vivo, may be an important target for the development of sepsis
This study was supported by the Korea Research Foundation's basic research project in the field of science and technology. (Professor Hong Suk-ryun), and the Basic Research Support Project (Basic Research (Professor Hong Sukman)).
The first author "Graphene oxide is a nanomaterial widely used in the biotechnological and medical fields, and it helps to identify the mechanism of inhibition of inflammatory response induced by iNKT cells graphene oxide at the cellular and molecular level. "It is expected that the research will be applied as a nano platform," if water release and cytotoxicity mechanisms in water are revealed and as biologically appropriate graphene oxides with side effects weaker are developed, in vivo applications will be accelerated and widely used as vectors for the control of various inflammatory diseases. "
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