Identification of intercellular signals that promote cancer metastasis

It turns out that the immune cells that protect our bodies are changed to "Hyde". rather than in "Jekyll", and that cancer metastasis is favored. Dr. Darren Williams of the Kwangju Institute of Science and Technology and a research team led by Jeong Da-hoon identified the process of promoting cancer metastasis by exchanging signals between cancer cells and immune cells and fibroblasts

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Cancer cells have the ability to control the surrounding microenvironment in their favor. Macrophages, which are immune cells that must attack cancer cells, also help cancer growth and the formation of metastases in the tumor microenvironment. As cancer cells communicate with surrounding cells, the process of signal exchange is very important in the growth and metastasis of cancer, but it is too complicated to study because it is too complicated.

The team studied signal transduction between cancer cells, fibroblasts and macrophages. It has been demonstrated that specific signaling substances secreted by fibroblasts by cancer cells proliferate, among which interleukin-6 and granulocyte macrophage colony stimulating factor (GM-CSF) jointly enhance macrophages. promoting tumors. 19659002]

We also proposed a way to block signal transduction between cells and inhibit cancer metastasis. The administration of anti-interleukin-6 and anti-GM-CSF antibodies to murine models that caused the cancer markedly reduced the number of tumor-promoting macrophages and significantly reduced cancer growth. and metastases.

Research Professor Jeongdoonun said, "This study has identified the major drivers for the exchange of cancer cells, fibroblasts, and immune cells, and presented a new vision of the strategy for suppressing cancer. cancerous metastases.

Professor Darren Williams said, "In the future, it will be important for chemotherapy to inhibit macrophages favoring tumors as well as cancer cells." In order to inhibit the conversion of macrophages into tumor-promoting phenotypes, will be effective. "The results of this research were published in the International Journal on June 29th.

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