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According to one study, people with low birth weight were 2.1 times more likely to have heart and cerebrovascular disease and a 2.4-fold higher risk of death than those with normal weight. In addition, the risk of cerebral angiogenesis and death in obese individuals was 0.7 times lower than that of the normal group. What we call the "paradox of obesity" is.
In a follow-up study of patients undergoing stent-type surgery to narrow the coronary arteries, low birthweight patients were more likely to undergo surgery than those with normal weight or d & # 39; obesity. The prevalence of major cardiovascular complications is higher than that of patients with type 2 diabetes.
It is shown that the paradox of obesity (a phenomenon according to which patients with obesity are rather better observed in clinical outcomes), confirmed by existing research on cardiovascular disease in Westerners, can be applied to Korean patients with intervention of a stent.
According to the World Health Organization (WHO), body mbad index (BMI /), underweight (less than 18.5%), normal body weight (18.5 less than 25%). ), Overweight (less than 25 to less than 30) and obesity (over 30).
After the intervention, the incidence rate of various diseases, including cardiovascular disease, stent reoperation and mortality rate, was examined once a quarter for a total of 12 months. The study population was selected from individuals who have had interventions with the latest generation of drug-releasing stents over the past five years.
The study showed that curve J, which has the lowest risk of complications in the overweight zone and the higher risk of underweight and obesity, is applied to domestic patients. According to Kim, "this study shows that the risk of major cardiovascular disease increases by 7% every 1 year when the overweight index, which is 24.5, is lowered."
In detail, the risk of major cardiovascular and cerebrovascular disease (MACCE) was 2.05-fold in the low-weight group compared to the normal group, 0.81-fold in the overweight group and 0.72-fold in the group obese.
The mortality risk from cardiovascular disease was 2.36 times lower in the low-weight group than in the normal group, whereas it was 0.72-fold lower in the obese group.
In addition, the reintervention rate after one year of reoperation was also more than three times that of normal-weight patients in the low-weight group, but remained at 0.74 times in the obese group.
Researchers believe that various factors have contributed to this phenomenon. First, it was noted that the proportion of coronary artery calcifications was higher in the low-weight group who underwent surgery compared to the other groups. Calcification of blood vessels is a symptom of calcium scarring in the coronary arteries caused by calcium build-up in the wall of blood vessels as well as other wastes, resulting in narrowing of arterial blood vessels and loss of blood. 39; elasticity.
The incidence of vascular calcification in the low-weight group was 20%, which was significantly higher than in the normal group (9.2%), the overweight group (6.4%) and the obese group (5.0%).
In addition, a low body weight is mainly due to insufficient nutritional intake, so that the health of the whole body of the low weight group is lower than that of the normal group or obesity group.
The risk of cardiovascular and cerebrovascular disease due to various badociated diseases such as cancer, autoimmune diseases and inflammatory diseases leading to low birth weight is also irrelevant.
Professor Kim said, "However, these results should be interpreted to mean that we must maintain adequate weight and not lead to unnecessary weight gain for patients."
In fact, the study also showed that the incidence of "dyslipidemia", excessive in cases of diabetes, hypertension, blood lipids or lipid components, increased with obesity and it was difficult to see obesity as a preventative factor of cardiovascular disease after stenting. .
The results of the study were published in a recent issue of the International Vascular Review "Atherosclerosis".
Reporter Min Tae-won [email protected]
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