Remove biofilm from chronic disease

[서울=뉴스핌] Kim Yeong-seop = The bacterium is injured in our body or when the infection progresses, we form a biofilm group to increase antibiotic resistance and prevent the drug.

According to UNIST (Ulsan Institute of Science and Technology), Professor Robert Mitchell of the Department of Biological Sciences of the University (BALO, Bdellovibrio and Like Organism) removes biofilm from Gram-positive bacteria and makes it a nutrient .

The new physiological characteristics of Bello, known to be effective only for Gram-.

Professor Robert Mitchell of the Division of Life Sciences UNIST (left), and author of the first author, Dr. Hansol [사진=UNIST]

Bello is a bacterium that consumes Gram-negative bacteria. Bello is harmless to the human body while eating harmful pathogens for our body, and it has been noted as "living antibiotics", but Gram-positive bacteria can not be eaten.

Professor Mitchell caught a glimpse of Bello's trait and began to study the interaction of Gram-positive bacteria with Bello.

This figure shows the resolution of predatory bacteria in the biomembrane (green dot) of Staphylococcus aureus. It can be confirmed that the biomembrane has degraded after the treatment of the predominant bacteria. [자료=UNIST]

The researchers conducted a variety of experiments using Staphylococcus aureus, a representative Gram-positive bacterium.

As a result, the predatory bacterium Bdellovibrio Bacteriovorus HD100 was formed by staphylococci through proteolytic enzymes. I've found that it breaks down the biofilm and uses it as a nutrient. In a later experiment, it was found that Bello, who provided this nutrition, is actively eating Gram negative bacteria more than before.

Gram-positive bacillus includes pneumococcus, reptile, streptococcus, anthrax, lepidopteran, dipterida and tetanus. Gram negative bacillus is a representative example of Salmonella, Alzheimer's, Typhoid, Escherichia coli, Cholera, Gonorrhea, Meningococcus and Spiroheta.

Professor Mitchell said, "The biofilm of bacteria can be found not only in the human body but also in everyday life like the pipes and the water tanks through which the water flows. " Using the microbial decomposition effect of Bello,

The results of the study were published in the online edition of the International Journal of Microbiology and Ecology (Journal of the # 39; ISME) on May 31st.

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