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▲ The only flu vaccine from cell cultures in Korea, "Skysell Flu". Photo courtesy = SK Bioscience
Influenza A (flu), an acute viral infection that spreads easily to all ages, affects about 10% of adults and 30% of children worldwide, causing about 5 million serious cases and 500,000 deaths worldwide. The Food and Drug Administration estimates that about 25 million flu shots will be distributed this year. That's the amount that one in two people can vaccinate.
The flu can be prevented up to 90% by vaccination alone. The effectiveness of the vaccine will vary according to the age of the vaccinated, the underlying disease affected in the past, the degree of agreement between the vaccine and the prevailing virus, but if the vaccine matches to the prevailing influenza virus, I'll do it
The most important difference between influenza vaccines is "3" and "4". There are three types of influenza viruses A, B, C and A and B prevalent among the population.
Meanwhile, in Korea there were mainly two types of antigens A and one of B antigens, three types of vaccines blocking the vaccine. However, as the number of cases of type B virus that are not included in the 3-influenza vaccine increases, the need for the 4-influenza vaccine is heightened for a broader prevention effect. The four-flu vaccine is a vaccine added to the three previous strains of the B virus.
Another difference that distinguishes influenza vaccines is how viruses are grown. Most influenza vaccines currently used are produced from fertilized eggs. It was developed in the 1940s and has existed for about 70 years.
The Yu-ran method usually requires one or two fertilized eggs to produce a vaccine of a dose 1. In order to be able to produce a large amount of vaccine, a considerable number of fertilized eggs must be obtained at the same time. advanced. It takes about 6 months between the preparation phase and the production of the vaccine and antibiotics must be administered to prevent contamination by various bacteria and viruses. This has limited inoculation to people with resistance or resistance to eggs or antibiotics.
Sensing the limit of the Yu-Ran method, the industry started using cells for the production of influenza vaccines from the 1980s. Since cell-based influenza vaccines produce vaccines in animal cells, they do not need to use eggs in the manufacturing process and do not administer antibiotics or preservatives. In addition, the vaccine can be vaccinated 2 to 3 months after the strain is secured, allowing for faster response when strains such as swine flu or Hong Kong flu prevail.
The US Centers for Disease Control and Prevention (CDC) are developing a vaccine against the H3N2 influenza A virus in the form of urine virus, which reduces the effect of the vaccine. I can do it
In Korea, the trivalent cell culture influenza vaccine was developed in 2015. It is SKYSSELL FLU, sold by SK Bioscience. SK Bioscience also markets the world's first four-cell flu vaccine, Skyshell Flu 4, developed worldwide in 2016.
Cell culture-based vaccine production technology, which is the core technology of SkySelve, was exported as a global vaccine company earlier this year. Exported cell culture vaccine production technology will be used to develop a new generation influenza vaccine to prevent virus variants.
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