The cause of male infertility … sperm head and tail protein & # 39; SPATC1L & # 39;

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This study is a kind of defragmentation. By looking at the germ cell components one by one, we will be able to reach the source of its production principle one day.

A key principle has been discovered that contributes to spermatogenesis in mammals, including humans. This is by the research team of the professor of the Department of Life Sciences of the Gwangju Institute of Science and Technology. On June 19th, the Korea Research Foundation stated that the SPATC1L protein was first discovered with the head and tail of sperm. This is another springboard for Korean researchers to diagnose the cause of male infertility, to develop a male contraceptive pill, and to identify the origin of the principle of sperm production.

SPATC1L, a specific protein that contributes to spermatogenesis, has been discovered for the first time by Korean researchers. SPATC1L connects the head and tail to the sperm neck and stabilizes the skeletal structure of the joint. [중앙포토]

[중앙포토]

The SPATC1L found that this time was a genetically modified organism, It acts as a link between the head and the tail of the sperm. In a word, the function of the sperm neck. The researchers found that SPATC1L is present at the junction between the head and tail of the mouse sperm, and plays a role in regulating other proteins to maintain the skeletal structure of the connective tissue.

We also used mouse gene scissors to create mouse models that do not express SPATC1L. Genetic scissors are artificial enzymes that are used to cleave specific DNA sites using techniques used to correct genes in plant and animal cells. This resulted in the absence of SPATC1L in mice and the separation of the head and tail of all sperm without exception. No other physical abnormalities have appeared.

SPATC1L was removed from experimental mice and the head and tail of spermatozoa were separated without exception. The gene scissors technique (CRISPER / Cas9) was used in this experiment. [중앙포토]

Professor Chung Hee Cho, who led the research, said, "The number of genes expressed in sperm alone is close to 300," he said. Professor Cho explained, "We made antibodies against SPATC1L and added fluorescent material to make it easy to observe." "We were able to visually observe a specific protein that shone only in the sperm neck. [중앙포토]