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Neuralstem, Inc. (Nasdaq: CUR), a biopharmaceutical company specializing in the development of new drugs for the nervous system, has published an article on the transplantation of NSI-532.IGF1 in the scientific journal Scientific Reports. According to the document, NIR-STEM has developed its own patent (US Patent No. 9,750,769) .NSI-532.IGF1, a host of human neural stem cells, has been shown to enhance the cognitive function of the murine model of Alzheimer's disease.
The study was led by a team led by Dr. Eva Feldman, director of the Neurology Research Program and director of the ALS Center of Excellence of the University of Michigan's School of Medicine. The researchers transplanted neural stem cell lines into APP / PS1 mice with the Alzheimer's disease-related mutation gene.
NSI-532.IGF1 was injected near the hippocampus, which plays a key role in the formation of brain memory. In addition, we measured the cognitive abilities of laboratory animals and the pathological condition of beta-amyloid plaques (Aβ), identified as being at the origin of Alzheimer's disease. Laboratory animals with neural stem cells improved their cognitive control-related abilities by performing two memory tasks that rely on the function of the hippocampus. In addition, control-related beta-amyloid-related pathology is impaired.
Dr. Karl Johe, Ph.D., senior scientist at Neurstem, said, "The current clinical development process for neural stem cell processing, NSI-566, is a treatment for stroke, spinal cord and Alzheimer's disease.NSI-532.IGF1 is a candidate for new generation stem cell therapy and aims to treat degenerative diseases such as Alzheimer's disease by combining stem cells Neural Factors with the Neuroprotective Protein IGF-1 This is a preclinical study conducted by Dr. Feldman's team, which suggests that the combination of neural stem cells with IGF-1 could reduce the decline cognitive and pathology due to Alzheimer's disease. "
"Alzheimer's disease is a major cause of dementia," said Dr. Feldman. "Our team has achieved interesting results by injecting human neural stem cells into a good animal model," said Dr. Feldman, "and we will continue to work with Neural System in the future."
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