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Taking low-dose aspirin to prevent heart disease and stroke is associated with an increased risk of bleeding into the skull in people without a history of these conditions, according to a new report. data from 13 previous studies involving more than 130,000 people. 42 to 74 year olds, who had no history of heart disease or stroke, received aspirin or placebo for the prevention of these conditions. All trials focused on the risk of bleeding to the head. People taking the placebo had a risk of head bleed of 0.46% during the combined test periods. For those taking aspirin, the risk was 0.63%, equivalent to an additional 2 in 1,000 people with bleeding, according to a study published in the journal JAMA Neurology on Monday. . (Related video below: Doctors Reverse Daily Aspirin Recommendations Preventing Heart Attacks, Strokes) People of Asian descent and those with a body mass index below 25 years of age had the highest risk. High. Daily low dose aspirin was previously recommended to the elderly because of its known ability to prevent platelet formation. a clot. In people with fatty deposits in the arteries, called arteriosclerotic plaques, they can rupture and cause clotting, which obstructs blood flow to the heart or brain. Although aspirin can theoretically stop this process. The authors of the new study explained that three large recent studies had concluded that daily low-dose aspirin was at best a waste of money for elderly people in good health. health. In the worst case, this could increase the risk of internal bleeding and premature death.Because of this evidence, aspirin is no longer recommended as a preventative measure for older adults not presenting a high risk of existing heart disease or heart disease, according to guidelines The American College of Cardiology and the American Heart Association announced in March: "Clinicians should prescribe aspirin very selectively to people not suffering from known cardiovascular disease, "said Dr. Roger Blumenthal, a Johns Hopkins cardiologist, who co-chaired the March Guidelines a statement. "It's much more important to optimize lifestyle and control blood pressure and cholesterol than to recommend aspirin." Aspirin should be limited to people with a higher risk of cardiovascular disease and a very low risk of bleeding, "he said, according to Blumenthal. you are aging or developing kidney disease, heart disease, diabetes and high blood pressure.History of ulcers or bleeding, especially in the gastrointestinal tract, or anemia are some drugs, such as that nonsteroidal anti-inflammatory drugs, steroids, direct oral anticoagulants and warfarin, a blood anticoagulant, can also increase the risk of bleeding.Because bleeding to the head is often catastrophic and that the benefits of a Low dose aspirin is not beneficial Well established, doctors should be cautious when prescribing this drug to people who are not sick. symptomatic ardiovascular, said the authors of the study.
Taking low-dose aspirin to prevent heart disease and stroke is associated with an increased risk of bleeding from the skull in people without a history of these conditions, according to a new report.
The researchers analyzed data from 13 previous studies in which more than 130,000 people aged 42 to 74, having no history of heart disease or stroke, had received Aspirin or placebo for the prevention of these conditions. All trials reported a risk of bleeding to the head.
Placebo participants were at 0.46% risk of head bleed during the combined trial periods. For those taking aspirin, the risk was 0.63%, equivalent to an additional 2 in 1,000 people with bleeding, according to a study published in the journal JAMA Neurology on Monday. .
(Related video below: Doctors reverse the daily recommendation of aspirin to prevent heart attacks)
People of Asian descent and those with a body mass index <25 years of age had the highest risk.
Daily low-dose aspirin was previously recommended for the elderly because of its known ability to prevent platelet clot formation. In people with fatty deposits in the arteries, called arteriosclerotic plaques, they can come off and cause clotting, which obstructs blood flow to the heart or brain.
Although aspirin could theoretically stop this process, previous studies had provided conflicting evidence as to whether its prescription increased the risk of bleeding from the skull, said the authors of the new research.
Three major recent studies have concluded that daily low dose aspirin is at best a waste of money for healthy seniors. At worst, this can increase their risk of internal bleeding and premature death.
In light of these data, aspirin is no longer recommended as a preventative measure in the elderly not presenting a high risk of heart disease, according to recommendations published in March by the American College of Medicine. Cardiology and the American Heart Association.
"Clinicians should be very selective in prescribing aspirin to people not suffering from known cardiovascular disease," said Dr. Johns Hopkins cardiologist Dr. Roger Blumenthal, who co-chaired the March guidelines, in a statement. "It is far more important to optimize lifestyle and control blood pressure and cholesterol than to recommend aspirin.
"Aspirin should be limited to people with the highest risk of cardiovascular disease and a very low risk of bleeding," he said.
Patients should work closely with their doctors to establish their risk of bleeding, said Blumenthal. This risk increases as one gets older or develops kidney disease, heart disease, diabetes, and high blood pressure. A history of ulcers or bleeding, especially in the gastrointestinal tract, or anemia are also risk factors. Certain medications, such as nonsteroidal anti-inflammatory drugs, steroids, direct oral anticoagulants, and warfarin, a blood-thinner, may also increase the risk of bleeding.
Since bleeding to the head is often catastrophic and the benefits of low-dose aspirin are not well established, doctors should be cautious when prescribing this drug to people who do not have Symptomatic cardiovascular disease, said the authors of the study.
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