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London .- A compound tested in mice could reverse hair loss and graying, as well as other skin damage associated with diets high in fat and cholesterol, according to a study published today. By Scientific Reports.
According to research – conducted by the Johns Hopkins University School of Medicine – the mixture would slow down the production of certain fats called glycosphingolipids (GSL), which are found in the skin and d & # 39; other cell membranes.
GSL fats are related to hair loss and other skin damage, as explained by the experts involved in the study.
Its production could be stopped with the compound D-PDMP, made with D-threo-1-phenyl. -2-decanoylamino-3-morpholino-1-propanol and which was tested in a group of mice.
These findings were extracted after feeding, from 12 weeks to 20 weeks of age, a group of mice with a Western diet high in fat and cholesterol, and a second group with a standard diet.
Compared to those who received standard food, mice with Western nutrition lost and suffered graying hair as well as skin lesions.
These results became more severe when the mice continued on a Western diet for 36 weeks, with 75% of the rodents having hair problems and multiple skin lesions.
"Our results show that a Western diet causes hair loss and graying and inflammation of the skin in mice. We believe that humans who consume a diet high in fat and cholesterol live a similar process, "said Dr. Subroto Chatterjee, professor of pediatric medicine at Johns Hopkins University.
The study, funded by the National Institutes of Health, In turn, he showed that by giving the mice the compound D-PDMP, the symptoms are reversed.
However, the experts said that this evidence does not mean that the mixture is safe and has the same effect in people. 19659002] Despite this They argue that the study highlights possible ways to stop hair loss and skin damage in humans by topical or oral medications.
"More research is needed, but our results He They promise to one day use a drug for skin diseases like psoriasis and injuries resulting from diabetes or plastic surgery, "Chatterjee said.
In this sense, previous studies have shown that GSL are present in the cells that form the upper layer of the skin, as well as in the keratinocytes, cells responsible for regulating the pigmentation of the eyes, skin and skin. hair.
how the alteration of the GSL could affect the appearance and color of the skin, as well as guarantee the effectiveness of D-PDMP treatment, would cancel any negative effect.
"We hope that in a day, this could mean a new baldness recovery fast and effective, graying hair in aging populations and healing wounds," said Dr. Chatterjee. EFE
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