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A compound tested in mice could reverse the fall and graying of hair as well as other skin damage related to diets high in fat and cholesterol, according to a study published today (July 30, 2018) by Scientific Reports.
According to research – conducted by the Johns Hopkins University School of Medicine – the mixture would slow down the production of some fats called glycosphingolipids (GSL ), which are found in the skin and in other cell membranes
Fats GSL would be related to hair loss and other skin lesions, as explained by the experts involved in l & # 39; study.
Its production could be stopped with the compound D-PDMP, made with D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol and which was tested in a group of mice.
These findings were drawn after feeding, from 12 weeks to 20 weeks, of a group of mice with a Western diet high in fat and cholesterol, and a second group with a standard diet.
Compared with those who received standard food, mice with Western nutrition lost and suffered graying hair as well as lesions in the skin . These results became more severe when mice continued to eat a Western diet for 36 weeks, with 75% of rodents having hair problems and multiple skin lesions.
"Our results show that a Western diet causes hair loss and graying and inflammation of the skin in mice. We believe that humans who consume a diet high in fat and cholesterol live a similar process, "said Dr. Subroto Chatterjee Professor of Pediatric Medicine at Johns Hopkins University . 19659003] The study, funded by the National Institutes of Health, showed that by giving the mice the compound D-PDMP, the symptoms are reversed.
However, experts have pointed out that this evidence does not mean that the mixture is safe and has the same effect on people.
Despite this, they argue that the study sheds light on possible ways of curbing hair loss and skin damage in humans with drugs . Topical or oral.
"More research is needed, but our results are promising for one day using a drug for skin diseases such as psoriasis and the resulting injuries." In this regard, previous studies have showed that GSL are present in the cells that make up the upper layer of the skin, as well as in the keratinocytes, the cells . responsible for the regulation of pigmentation of the eyes,
Determining how the alteration of the GSL could affect the appearance and color of the skin, as well as guarantee the efficacy D-PDMP, would cancel any negative effect.
"We hope that someday in the future this could mean a faster and more effective recovery of baldness, graying hair in aging populations and healing of wounds," he said. Dr. Chatterjee
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