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Diabetics depend on insulin that they must inject daily, but a new method based on pills that has not yet been tested in people could change the way patients maintain their blood sugar, according to a new study. study published today by PNAS
The oral administration of insulin can not only improve the quality of life of more than 40 million people with type 1 diabetes worldwide, but it could also alleviate many of the side effects of insulin. the disease, according to the team at Harvard University who developed the method.
Insulin therapy by injection usually keeps glucose levels in the right order, but many people do not have good adherence to treatment, either because of phobia. According to the director of the study, Samir Mitragotri, or because it interferes with their usual activities
Until now, it has been difficult to find a method to administer oral insulin, because that the protein does not grow well when it is in the acid environment of the stomach and that it is poorly absorbed outside the intestine.
The new approach developed by the team is to take insulin in an ionic liquid composed of choline (an essential nutrient similar to a protein) and geranic acid (used as a food additive ) which is enclosed in a capsule with an acid-resistant enteric layer.
It is, according to a university statement, a "biocompatible" elebaoración, easy to produce and can be stored for up to two months at room temperature without degrading. "
Mitragotri explained that once ingested," the insulin must navigate a difficult obstacle course before it can be effectively absorbed. by blood.
Oral insulin ingestion, indicates the note, would more faithfully reproduce the way a healthy pancreas
The team now wants to perform more animal testing on the formulation, as well as toxicological studies and long-term bioavailability.
In the event that everything goes well, scientists expect that getting approval of possible clinical trials with people is easier because choline and acid geranium are already considered safe.
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