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According to the agency, in one of the studies, it was also possible to note Anvisa ) published Tuesday an alert to the badociation between cancer of the lip and the exposure to the drug . Photo: Fabio Rodrigues Pozzebom / Agência Brasil
The National Sanitary Surveillance Agency The Increased Risk Of Non Melanoma Skin Cancer Resulting From The Cumulative Use Of Hydrochlorothiazide , a drug used for the treatment of high blood pressure and control of oedemas . [19659005] "The discovery was made through epidemiological studies that demonstrated a dose-dependent cumulative badociation – which occurs when the dose of a particular drug is directly related"
According to the report. agency, in one of the studies, it was also possible to note a possible badociation between cancer of the lip and skin cancer without melanoma. exposure to the drug. "The photosensitizing actions of hydrochlorothiazide, which facilitate its absorption through the skin, may act as a possible mechanism of the disease."
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Generics and similar products occupy 65% of the domestic market, explains Anvisa. Anvisa Anvisa Anvisa Anvisa Anvisa also endorsed the recommendations of the Committee of the Regions Pharmacovigilance Risk Assessment of the European Medicines Agency to categorize as plausible the pharmacovigilance of the European Medicines Agency. badociation between an increased risk of non-melanoma skin cancer and the long-term use of drugs containing hydrochlorothiazide
In a statement, the agency asked health professionals to inform patients treated with hydrochlorothiazide of the risk of skin cancer – already use the drug in the long term. They should also be advised to regularly check the skin for new lesions and to inform the professional immediately of any suspected skin lesions.
The Anvisa indications are that the treatment should not be interrupted before. consult the doctor. "Suspected skin lesions should be examined promptly, including histological examination of biopsies." Preventive measures, such as limiting exposure to the sun and ultraviolet light, can be implemented to minimize the risk of skin cancer.The use of hydrochlorothiazide may be reconsidered in patients with a history of skin cancer other than melanoma. "
The inclusion of new information in the leaflets of all medicinal products containing the active ingredient hydrochlorothiazide will be immediately requested by the Agency [19659005] Skin Cancer
Non-melanoma skin cancer includes the most common tumors common in light-skinned people after prolonged exposure to the sun. Generally, they only show local growth, but do not heal without treatment and tend to increase over time, causing deformities, pain and bleeding.
Data from the National Cancer Institute (INCA) indicate that there is the type of cancer in Brazil and accounts for 30% of all malignancies registered in the country. If detected early, the disease has high percentages of cure. Among skin tumors, the non-melanoma type is the one with the highest incidence and the least mortality. Anvisa reported that he was constantly monitoring the drugs marketed in Brazil and
Communication of suspected adverse events by patients can be established via the Public Assistance Center form (0800 642 9782). or by the office of the mediator (ouvidori @ tende)
For health professionals, Anvisa provides the Notivisa system in case of notification of adverse events.
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