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RIO – Researchers at Scripps Research (USA) demonstrated this week that an HIV vaccine test could be effective in non-human primates. an HIV strain resembling the resistant viral form that most commonly infects people, called the Tier 2 virus.
The survey also provides the first estimate of the neutralizing antibody levels needed for protection against HIV induced by vaccination.
] – We found that vaccine-induced neutralizing antibodies can protect animals from viruses that are very much like HIV in the real world – says Dennis Burton, head of Scripps' Department of Immunology and Microbiology. Scientific Director of the International AIDS Vaccine Initiative.
Burton points out, however, that the possibility of death developing clinical trials on human and development of an HIV vaccine
The purpose of this study is to Identify rare and vulnerable areas of the HIV virus and teach the immune system to produce antibodies to attack these areas. conducted by Scripps Researchers have shown that the body needs to produce neutralizing antibodies that bind to the virus. To support this idea, scientists have found that they can protect animal models of HIV by injecting neutralizing antibodies produced in the laboratory
. The team tested the vaccine on two groups of rhesus monkeys. An earlier study using the same vaccine had shown that naturally immunized monkeys developed varying vaccination rates.
Primates were then exposed to a form of the virus called SHIV, an artificial version of HIV that has similar characteristics.
This particular strain of the virus is known as Tier 2 virus because it has proven difficult to neutralize as well as the circulating forms of HIV in the human population
The researchers found that the vaccination was effective against primates that produced sufficient levels of neutralizing antibodies. Now the question is how to extend this effectiveness to all animals and then promote a vaccine project to be tested on humans.
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