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Annie Cavanagh / Wellcome Images
A new drug has the potential to cure patients with aggressive brain cancer: glioblastoma. That's what a study done at Sheba Medical Center in Israel
says. The need to conduct research on the disease is that there is no cure and that the results of current treatments are limited.
The science knows that thrombin, a blood coagulation factor that is expelled by tumor cells, and PAR1, a protease-activated receptor (an enzyme that breaks down proteins and peptides) is one of the tumors themselves. same and is responsible for the evolution of the disease.
Call SIXAC the drug consisting of six new amino acids, inhibits the activation of PAR1 – according to the study published in the review Fronties in Neurology of 17 November.
For the moment, the drug was only tested in on tumor models in the animal but was effective: it slowed the progression of the disease, its multiplication and ability to penetrate brain tissue, according to Exame magazine.
In 10% of animals with high-grade malignancies, the drug extended its life and came to cure them of the disease . Glioblastoma can also affect the spine, but the study was conducted with a focus on the brain tumor.
Researchers expect to badyze their findings in humans as soon as possible. SIXAC would be implemented as a complementary treatment to chemotherapy, with the goal of prolonging and improving the quality of life of patients with the disease.
Nevertheless, despite the promises of the investigators' efforts, they warn that the success of the news will depend not only on scientific progress, but also on funding.
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