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A Belgian team's link discovered that bacteria present in the flora can affect mental balance, especially when there is a risk of depression.
Researchers at KU Leuven University badyzed stool samples of 1,054 people and found that two families of bacteria were consistently smaller in depressed participants, including those on drug therapy: the study of a control population composed of 1,063 Dutch validated the conclusions of a state link
The bacterial families involved – Coprococcus and Dialister – are known for their anti-inflammatory properties. In the intestine. "We also know that nerve tissue inflammation plays an important role in depression. Therefore, our hypothesis that both are linked in one way or another, "said Jeroen Raes, professor of microbiology at the Belgian University and one of the authors of the study (AFP).
has also created a catalog of intestinal microbiome functions based on the ability to produce or degrade molecules potentially interacting with the human nervous system, linking this catalog with genetic material data from the human body. 39; faecal sample of a subgroup of the group of volunteers, including patients with a more traditional resistant depression.The results showed an badociation between the ability of intestinal flora to synthesize a metabolite of Dopamine – low levels of this neurotransmitter are linked to depression – and the quality of mental life of patients
Early stages
According to Jeroe n Raes, the study in establishes a cause-and-effect relationship between bacteria and depression. The understanding of the links between the intestine and the brain is a scientific matter, and the Belgian work goes a little in that direction. "Until now, most of the studies were on mice or a small number of people, and the results were mixed and contradictory," he said.
However, the team does not rule out this link being exploited from the point of view. therapeutic. "The idea that substances derived from the metabolism of microbes can interact with our brain – and therefore with our behavior and feelings – is intriguing," said Jeroen Raes. "I really think about the future: use mixtures of bacteria as treatment."
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