as the hangover led to the discovery of one of the most popular remedies in the world



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Stewart Adams knew that he had found a new pain medicine after being cured of a hangover just before pronouncing an important speech.




  Stewart Adams died on January 30 at the age of 95 "src =" https://p2.trrsf.com/image/fget/cf/460/0/images.terra.com/2019 / 02/05 / Stewart Adams died on January 30 at the age of 95. "Stewart Adams died on January 30 at the age of 95."
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<p>  "I was the first to talk and I had a bit of a headache after a night out with friends, so I took a dose of 600 mg, alone." badure, and I thought it was very effective. "</p>
<p>  Adams died last Wednesday at the age of 95. In 1992, the pharmacist recalled in an interview with the BBC his years of research, the numerous tests performed on the compounds and the many disappointments before he and his team reached ibuprofen. </p>
<p>  Since the adoption and marketing of this medicine 50 years ago, ibuprofen has become one of the most popular painkillers in the world. It is difficult to find a medicine cabinet without these pills. </p>
<p>  Do you have a fever? Headache? Back pain? Teeth ache? It is therefore likely that ibuprofen is the drug of choice for treating your symptoms because it acts quickly and is available even in supermarkets. </p>
<p>  However, the British National Health Service warns that the drug should be taken at the lowest dose and for the shortest possible time, as it can cause side effects such as nausea and vomiting. </p>
<p>  Its popularity for the treatment of pain is not just a phenomenon on British territory. In India, for example, it is the treatment of choice for fever and pain and, in the United States, it is an over-the-counter drug since 1984. It is also used to treat inflammation in the setting of diseases such as arthritis. </p>
<p>  Adams noticed during a trip to Afghanistan in the 1970s that even the remote pharmacies of the village located along the Khyber Pbad had sold their discovery. </p>
<h3>  The Search for a Challenge </h3>
<p>  It all started with a 16 year old boy from Northamptonshire, England, who left school without a project for the future. </p>
<p>  He was an apprentice in pharmacy at Boots today. An extensive branch network and experience led him to pursue a degree in pharmacy at the University of Nottingham, followed by a Ph.D. in pharmacology at the University of Leeds, before returning to Boots research department in 1952. </p>
<p>  The mission at the time was to find a new treatment for rheumatoid arthritis as effective as a steroid but without any side effects. </p>
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  Stewart Adams spent his entire career at Boots researching and developing nonsteroidal anti-inflammatory drugs "src =" https: / / /p2.trrsf.com/image/fget/cf/460/0/images.terra .com / 2019/02/05 / 86674333stewartadams.jpg "title =" Stewart Adams has spent his entire career at Boots on non-inflammatory research and development. steroids "width =" 460 [19659003] Stewart Adams spent his entire career at Boots, researching and developing nonsteroidal anti-inflammatory drugs
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<p>  He began to be interested in anti-inflammatory drugs, and in particular in the operation of aspirin, which no one seemed to be doing. </p>
<p>  Photo: BOOTS UK / BBC News Brazil </small>
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<p>  Nonsteroidal anti-inflammatory drug to be developed in 1897. Even though it was commonly used as an badgesic at the time, it had to be administered in doses very high. As a result, the risk of side effects such as allergic reaction, bleeding and indigestion was high. . </p>
<h3>  Ten Years of Research </h3>
<p>  In search of an alternative, Adams recruited chemist John Nicholson and technician Colin Burrows to help test the potency of more than 600 chemical compounds. The key was to find a drug well tolerated by the body. </p>
<p>  From the living room of an old Victorian house in the suburb of Nottingham, the small team patiently tested the compounds until it discovered something of interest in the tests clinics. </p>
<p>  Adams realized that his chances of success were minimal, but he and his team persevered for ten years. </p>
<p>  "I thought we would finally succeed, I always thought we would succeed." </p>
<p>  And he was always ready to play the guinea pig role by testing two or three compounds per se. . </p>
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  Ibuprofen is now produced by a number of companies

Ibuprofen is now produced by several companies.

Adams admitted that it would never be allowed nowadays, but at least stated that they took care to conduct toxicity tests in advance.

"It was important to test them and I was delighted to be the first person to take a dose of ibuprofen."

Meanwhile, four drugs were clinically tested and failed before reaching the compound in 1961, called 2- (4-isobutylphenyl) propanoic acid or phenyl isobutylpropanoic acid, which will later become ibuprofen.

A patent for the substance is granted to Boots in 1962 and approved as a prescription drug seven years later

According to Dave McMillan, former Health Development Officer at Boots UK, ibuprofen was an extremely important medicine for the society.

"This saved Boots and contributed to its expansion in the United States and around the world.number one of Boots."

20,000 tons of ibuprofen are produced each year by a number of companies under different brands.

Adams is honored for his research by an honorary doctorate in science from the University of Nottingham and two plaques from the Royal Society of Chemistry. He remained at Boots until the end of his career, becoming Chief of Pharmaceutical Sciences.

What pleased him the most was that hundreds of millions of people around the world were taking the medications that he had discovered.

way – and it all started with a headache.

How does ibuprofen work?

This is a nonsteroidal anti-inflammatory drug. Because it has a different chemical structure than steroids, ibuprofen is not so toxic.

It reduces pain by targeting compounds called prostaglandins, which cause inflammation in the body. The inflammation can cause swelling, heat, redness, loss of function, fever and pain.

The badgesic effect begins shortly after taking the dose, but the inflammation may take longer to subside.

been in the treatment of minor pains. But like any medicine, it has side effects, especially if its use is continuous. The risk of heart attack and miscarriage is one of these, as well as less severe reactions such as nausea and vomiting.

Last year, researchers at the University of Copenhagen discovered other effects of prolonged use of ibuprofen, such as male infertility , muscle wasting, fatigue and erectile dysfunction. ? Subscribe to our channel!

https://www.youtube.com/watch?v=dGpz_-RzrzM [19659006] https: // www. youtube.com/watch?v=39e1N2g9rbE&t=6s

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