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[photo: Thiago Fagundes / Presse CB / DA] In search of ways to treat this high-incidence neurodegenerative disease in the elderly, Brazilian researchers, in partnership with foreign scientists, have decided to Analyze neuronal effects In experiments on rats, the team noted that the increase in muscle mbad related to the release of hormone iris was related to this advantage, and that the same substance was also produced by the brain.The findings were published in the latest issue of the journal Nature Medicine
.The authors explain that studies done at Harvard University in the United States showed that the hormone irisine was released during the practice of activities. Physical – improves, in rodents, the symptoms of type 2 diabetes. People with this metabolic disease are at higher risk of suffering from Alzheimer's disease. "They have proven to be memory inducers and have been proposed as an approach to reduce the risk of Alzheimer's disease," said the authors of the study published yesterday, led by Fernanda. Felice and Srgio Ferreira, both researchers from the Federal University of Rio de Janeiro (UFRJ). The work involved scientists from Columbia University in the United States, Queen's University in Canada, and the Oswaldo Cruz and Gold Institutes, also located in Rio de Janeiro.
Researchers badyzed mice treated for Alzheimer's disease under two conditions: by producing irisin during exercise or after receiving regular doses of hormone. Those in the first group were badyzed by swimming one hour a day for five weeks. The team determined that the activity increased the concentration of irisin and made the animals more apt to learn.
In the group of mice given regular doses of hormone, it was found that the procedure was able to remedy the memory loss caused by a neurodegenerative disease. . "Irisine is not a probable cause of early cognitive impairment in Alzheimer's disease, but it can contribute to memory loss," they noted.
The group also knew that there was less irisin in the brains of people with Alzheimer's disease – after the treatment. The death of brain tissue and cerebrospinal fluid from living patients led to this conclusion. The condition has been confirmed in the new experiment with rodents. "Reduced levels of irisin in the patient's brain and animal models support the idea that hormonal signaling of the brain is related to memory formation."
Varied
For the team, it is not necessary to define the number of physical exercises. be practiced throughout life to prevent the onset of Alzheimer's disease. But scientists believe that activities can be varied, not just swimming, as was the case for mice.
"The incidence of Alzheimer's disease, the most common form of dementia among the elderly, increases with the aging of the world's population, with over 35 million people affected worldwide Currently, there is no effective treatment against this disease and significant efforts have been made to develop strategies to fight the mechanisms leading to neuronal damage, synapse failure and memory disorders. " , they justify.
According to the researchers, studies may focus on "the precise physiological roles of the brain and irisine in the formation and consolidation of different types of memory". The team also does not rule out the creation of a medicine against the disease. Current medications help mask the symptoms of Alzheimer's, but they do not treat the underlying disease and do not delay its progression.
Word of the Expert
Promising Horizon
"More recently, irisin was linked to neuronal neurological behavior and metabolism, implying a role important in the brain.Studies have shown that exercise can help prevent or slow the development of Alzheimer's disease and other diseases badociated with age. Plausible investigations like this one, which link the two themes.Identify the molecular mechanism responsible for the beneficial effects of exercise could lead to new therapeutic strategies mimicking these effects, particularly in older people with the disease. Alzheimer's, better understanding the relationship between brain tissue and memory has important implications for the treatment of this disease, as well as for other neural diseases similar in their character.
Xu Chen, Researcher, Department of Neurology, University of California, in an opinion piece also published in Nature Medicine
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