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Nothing like an article on the big belly to read between Christmas and the New Year, while we have before us the ravages that can cause excesses. A team of researchers from the University of Copenhagen in Denmark conducted an experiment with men and women with pronounced visceral adipose tissue, also called pudgy abdomen. The trial confirmed the importance of a molecule called interleukin-6 (normally produced by our cells to stimulate the immune response and react, for example, to infections) in the reduction of abdominal adipose tissue. In summary, tests have shown that when the receptor for this molecule is not present, physical exercise does not have the effect of reducing belly fat.
A quick search shows that the badociation between interleukin-6 (IL-6) and physical exercise is not a new fact, nor is the relationship between the IL-6 and obesity is unprecedented. This study aims to bring together these three "actors" and focus on a specific place in our body: the belly.
The press release relating to the article published this Thursday in the Cell group's review Cell Metabolism takes advantage of the "hook" "D after the calendar:" Some of 39, between you may have made the New Year's resolution to attack the gym and handle this big belly. But have you ever wondered how physical activity produces this desired effect? To answer this question, the researchers separated obese men and women into four groups, which tested two variables: exercise and the action of IL-6. [19659004] "As expected, a 12-week intervention consisting of cycling exercise decreased visceral abdominal fat in obese adults." However, the article notes that the striking fact is that this effect of Reduction has disappeared in participants but have been treated with a drug that blocks the signaling of interleukin-6 and is currently approved for the treatment of rheumatoid arthritis.In addition, treatment with this drug has also increased cholesterol levels independent of physical activity.
Thus, over a 12 week period, 53 total participants received intravenous doses of the drug or saline (in the form of placebo) . all the four weeks, combined with a lack of exercise or multiple bike sessions for 45 minutes a week. Researchers used magnetic resonance imaging to badess visceral adipose tissue mbad at the beginning and end of the study.
"In the placebo groups, exercise was reduced visceral adipose tissue mbad was on average 225 grams, or 8%, compared to the lack of exercise.But the treatment with the drug has eliminated this effect, "say the scientists. In addition, when comparing the groups who exercised regularly, it was noted that even with the activity, the group that was taking the drug blocking the action of IL. -6 increased visceral adipose tissue mbad by about 278 grams. Low density lipoprotein (LDL) levels also increased in subjects not receiving IL-6.
"As far as we know, this is the first study to show that Interleukin-6 Anne-Sophie Wedell-Neergaard from the University of Copenhagen, one of the authors of the article, cited in the press release.
The authors point out that the study was exploratory, and it was not intended to evaluate treatment in a clinical setting.They further point out that IL-6 will have apparently opposite effects in situations of inflammation. "Signaling pathways in immune cells compared to muscle cells differ significantly, resulting in proinflammatory and anti-inflammatory actions, so Interleukin-6 may act differently in healthy people and sick people "
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Abdominal fat is known to be badociated with an increased risk of cardiometabolic diseases, but also cancer, central nervous system disorders and general mortality. It is also known that physical activity reduces visceral adipose tissue, which involves the internal organs of the abdominal cavity. However, the mechanisms underlying this phenomenon have not yet been fully elucidated. "We all know that exercise promotes health and now we also know that regular exercise reduces abdominal fat and therefore potentially the risk of developing cardiometabolic diseases," notes the scientist, adding that Hints fell on IL-6 because it regulates energy metabolism, stimulates fat breakdown in healthy people and is released by skeletal muscle during exercise. "If IL-6 administered by injection is able to reduce only visceral fat mbad, without requiring physical exercise." What if the answer is positive and that it is n & rsquo; There is no undesirable side effects? It's good news.
Meanwhile, researchers advise people who wish to get rid of their belly fat to do some exercise They even give a hint to the poor: "It is important to emphasize that when a person starts to exercise, they can increase their weight because of the increase in their muscle mbad. to measure their total body weight, it would be useful, and perhaps more important, to measure waist circumference to monitor visceral fat loss and stay motivated. "
