[ad_1]
The anti-inflammatory effects of a protein found in pineapple were added to bacterial nanocellulose. The result is the creation of a dressing – in the form of plaster or gel – that can be used for healing wounds, burns and even ulcerative wounds.
The novelty comes from a study of researchers from the University of Sorocaba Uniso) and the University of Campinas State (Unicamp). The work, supported by FAPESP, had results published in the scientific reports of the nature group.
In laboratory tests, bacterial nanocellulose membranes were submerged for 24 hours in bromelain solution, pineapple protein. The result was a ninefold increase in the antimicrobial activity of bacterial nanocellulose.
"Anyone with serious injuries knows very well the difference that makes a good bandage. It must create a barrier against microorganisms, avoid contaminations and be able to provide antioxidant activity to reduce the inflammatory process of dead cells and pus, "said Angela Faustino Jozala, coordinator of the Laboratory of Industrial Microbiology and Fermentation (LaMInFe ) from Uniso. In addition to increasing the antimicrobial property of bacterial nanocellulose, a selective barrier has also been created that potentiates protein activity and other important activities for healing, such as increased antioxidants and the vascularization.
"Integral skin has the biggest problem of contamination.The patient is likely to be infected either in case of burns, wounds or ulcer wounds.Bromelain creates such an important barrier," said Jozala.
Bacterial nanocellulose and bromelain are known to science and the pharmaceutical and food industry. Pineapple protein is used as a meat tenderizer and its property of protein breakdown, known as cell debridement, is of interest to the pharmaceutical industry.
Bromelain has the character of cleaning the necrotic tissue of the wound. and also form a protective barrier against microorganisms. However, because it is an enzyme, it has limitations of use in the industry, since it is easily denatured and degraded, in addition to being unstable in some formulations .
Bacterial nanocellulose can be applied as a temporary skin substitute or as a curative for the treatment of ulcerative lesions, as it relieves pain, protects against bacterial infections and contributes to tissue regeneration.
Like plant cellulose, bacterial nanocellulose is produced in pure form without other polymers. This gives it the ability to be shaped into three-dimensional structures capable of holding large amounts of water without hindering the gas exchange.
"It is a bio-plant.The bacterium Gluconacetobacter xylinus, for example, produces cellulose because it is a molecule of glucose polymers.What we did in our study was to potentiate, with bromelain, the healing action of this nanocellulose that we already produced in our bioproduction platform, "said Jozala.
Perfect Marriage
According to study, 30 minutes after being incorporated in bacterial nanocellulose membranes, greater release of bromelain and with greater capacity for antimicrobial action was observed.In addition to the badociation between bromelain and bacterial nanocellulose, the work had Another important partnership The Uniso research team has created, with the help of FAPESP, a platform for the production and purification of bioproducts. bacterial ellulosis is produced
Another project, also supported by FAPESP, and conducted at the Faculty of Pharmaceutical Sciences of Unicamp, began to study the extraction of bromelain present in the stem and the fruit of pineapple. ] "We were producing bacterial nanocellulose, but we wanted to extend the curative powers of the product." From a meeting with the Unicamp group, which has already extracted bromelain using the remains of the pulp industry, we saw that the junction had a future, "said Jozala
both the production of bromelain and bacterial nano-cellulose. the purification part of the substances – cost less using waste and the remains of the food industry, such as pineapple peels from companies that produce fruit pulp. Researchers are now looking to create new partnerships and generate business interest for large-scale production of the new dressing.
Bacterial nanocellulose loaded with bromelain: evaluation of antimicrobial, antioxidant and physico-chemical properties (doi: 10.1038 / s41598) -01718271-4), by Janaína Artem Ataide, Nathália Mendes de Carvalho, Márcia de Araújo Rebelo, Marco Vinícius Hot, Denise Grotto, Marli Gerenutti, Mahendra Rai, Priscila Gava Mazzola and Angela Faustino Jozala, can be found at .nature.com/articles/s41598-017-18271-4 # Sec9.
[ad_2]
Source link
