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In this study, mice genetically engineered to develop an Alzheimer's disease underwent one hour of swimming a day for five weeks or received irisine doses manipulated in the laboratory. "Animals with the disease model do not have memory, they are unable to learn tasks.With the treatment, this comes back.They were indistinguishable from normal animals.We observed in 100% of Between them that irisin, in addition to being good for memory, avoids degeneration in the neurons of mice – it has a neuroprotective effect and enhances synapses. that this allows the brain to function, "Ferreira told the O Estado de S. Paulo newspaper and in the cerebrospinal fluid of patients with Alzheimer's disease compared to healthy patients. The same deficit was observed in the mice with the model of the disease studied
Treatment
This does not mean, however, that the treatment tested in animals would have the same effect in humans, said the researcher. the research base, it is not possible to establish for example, the amount or amount of physical activity that could be produced from irisin to protective levels for the brain.
It works on the human being. We do not know if irisin has the same role in people's brains. The protein has never been studied in the brain before this work, "says Ferreira." But what our study suggests is that in the future, if the benefits of Irisine are reproduced for humans, they could be adopted as a kind of hormonal substitution, as is the case with insulin for diabetics, "he says.
"It's a work that also reveals how strategic it is to invest in this type of research, increasingly in Brazil, where the population is aging rapidly," says Ferreira. "Older people are becoming more numerous and elderly. Already 1 million more people with Alzheimer 's disease in Brazil, and this could triple in the next few years. If there is no very clear policy, the country will suffer a very hard blow, not only familiar, social, but also economic. "
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