"The artificial ovary" can help women become pregnant after chemotherapy



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Women with ovarian cancer may have decreased fertility
– WIKIMEDIA

RIO – Women who are undergoing chemotherapy and radiation treatments are at high risk of impaired fertility. To solve this problem, researchers at Rigshospitalet in Copenhagen, Denmark, are developing an "artificial ovary", built with human tissue and eggs, that can be implanted in cancer survivors. The technique, still at an early stage, may also benefit women with other conditions, such as multiple sclerosis and beta-thalbademia, which also require treatments that affect fertility.

Scientists Create Synthetic Embryos and Implant Them in Mice

Today, women diagnosed with cancer who wish to become mothers can freeze ovarian tissues before crossing the tissues of ovarian

treatments. After healing, the tissues are reimplanted and they can regain their fertility naturally. But in some cases, such as ovarian tumors and leukemia, cancer cells can affect the ovary's own tissues. In these situations, there is a risk that the reimplantation will reappear the tumor, rendering the technique unsuitable.

At Rigshospitalet, a team led by Susanne Pors believes that "artificial ovaries" could be a safer option. . At a presentation Monday at the annual meeting of the European Society of Human Reproduction and Embryology in Barcelona, ​​the researchers presented a technique that involves "creating" a new ovary.

With chemical agents, scientists removed all cells from donor ovarian tissue, including cancer cells. In the bare tissue, essentially collagenous, were implanted human follicles, small sacs that store the eggs until they are matured. In the laboratory, the researchers implanted one of these "artificial ovaries" with 20 follicles in the mouse and, after three weeks, the blood vessels already provided the ovary inside the larynx. animal

– This is the first proof. This is a milestone on a long road, "Susanne told the Guardian

Among the experts, the experiment was greeted with hope, but provided that clinical trials did not occur have been made to prove the effectiveness of the new technique.

– The possibility of creating a "new ovary", by removing any tissue that can reintroduce cancer, allows the re-implantation of a safe ovary with a potential to successfully restore fertility, "said Adam Balen of Seacroft Hospital in Leeds, England, does not participate in the research. It is still a proof of concept, with human tissue transplanted into the mouse to demonstrate that the transplant can work, but it must undergo clinical trials.

The BBC, Stuart Lavery, a gynecologist at Hammersmith Hospital, pointed out with respect to current in vitro fertilization treatments, allowing women to get pregnant "naturally." Gillian Lockwood, director of Midlands Fertility, notes that the implantation of follicles allows women to restart their menses, avoiding hormone replacement therapy.

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