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A molecule developed at the Institute of Biomedical Sciences of the University of São Paulo (ICB-USP) could improve the quality and lifespan of people with heart failure – currently about five years for the most of them. The new molecule – manufactured by the ICB in cooperation with Stanford University in the United States – paves the way for new drugs capable of slowing the progression of the disease more effectively than those already available
& nbsp; & nbsp; & nbsp; & nbsp; & nbsp; Heart failure is the latest stage of various cardiovascular diseases, which kills the most in the world, according to the World Health Organization (WHO). An estimated 17.7 million people died of cardiovascular disease in 2015, representing 31% of all deaths worldwide.
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"Most of the drugs available today To treat heart failure were developed in the 1980s and act outside the heart cell.We need more effective drugs that control the critical processes of the cardiac cell overdue, this that can increase the duration and quality of life of patients.But this task is arduous, "said Julio Cesar Batista Ferreira, professor and coordinator of the study.
According to the ICB, treatment with the new synthetic molecule, called Samba, slowed the progression of heart failure in animals. Rats with heart failure treated for six weeks with the molecule showed not only a stabilization of the disease – as with current drugs – but also a regression. The animals had an improved contraction capacity of the heart muscle.
The molecule has also been tested on human heart cells. The results showed that, in addition to slowing the progression of the disease, there was an improvement in the ability of these cells to contract. "The current drugs slow down the progression of the disease, but they never make it disappear.What we show is that by regulating this specific interaction, the progression is slowed down and still brings the disease to a lighter stage. "
The research and the new synthesized molecule were described in an article published in Nature Communications last Friday (18). The Natural Science Publication is one of the world's leading scientific journals and covers topics related to physics, chemistry, earth sciences and biology.
Edition: Talita Cavalcante
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